Immunology: T cell Development & Activation MCQ

Multiple Choice Question on T cell Development, Differentiation, and Activation

1) T cells (T lymphocytes) are crucial in the recognition of antigens presented by self-MHC. The T cell progenitors undergo proliferation and differentiation in the thymus and form a mature T cell. 
Which of the following organ is the origin of T cell progenitors?
a) Thymus
b) Hepatocytes
c) Bone marrow
d) None of the above

2) What is the characteristic feature of progenitor T cells that have migrated to the thymus?
a) They express T cell receptor/CD3 complex
b) They express CD28 cell adhesion molecule
c) They express CD4 or CD8 co-receptor
d) None of the above

3) Which of the following cell adhesion molecule is present in the T cell progenitors required for homing these cells into the thymus?
b) CD44
c) IL-2
d) CTLA-4

4) Pre- T cell receptor complex consists of the β chain of TCR & CD3 molecules that are formed during the proliferation of T cells. 
 The function of the pre-TCR complex includes all of the following, except?
a) signal productive rearrangement of TCR β for further proliferation
b) suppress further rearrangement of β chain (allelic exclusion)
c) prepare cells for rearrangement of α chain
d) commit T cells for CD4 or CD8 positive T cells

5) Which of the following is the process for T cell development and maturation?
a) Rearrangement of T cell receptor and expression of coreceptors
b) Positive selection of thymocytes bearing receptors that are capable of binding to self-MHC molecules (MHC restriction)
c) Negative selection ensures the affinity receptor self MHC or MHC antigen complex is eliminated (self-tolerance)
d) All of the above

6) During the differentiation of T lymphocytes, the double-positive cells are directed to become CD4 + T cells & CD8+ T cells which are MHC II & MHC I restricted respectively. 
Which of the following process might be the correct for T cell differentiation?
a) Intrinsic model- multiple interactions of MHC with double-positive (CD4+ & CD8+) instruct the cell to differentiate
b) Stochastic model- CD4 or CD8 expression in switched of randomly
c) Both A and B
d) None of the above

7) The activation of T cell requires the interaction of MHC/peptide of TCR/CD3 complex activation requires the expression of.................................................
a) Transcription factors such as c-Fos, c-Myc, c-Jun, etc.
b) Interleukins such as IL-2, IL-3, and IL-6
c) Adhesion molecules such as CD28, CTLA-4
d) All of the above

8) Which of the following cytoplasmic tail of CD4 or CD8 coreceptors are required for phosphorylation of ITAM present in CD3 molecules?
a) Lck
b) ZAP70
c) LAD
d) None of the above

9) The cell surface proteins on T cell bind to B7 on the antigen-presenting cells and serve as a secondary signal. 
Which of the following statement is true regarding the secondary signal?
a) CD28 is a protein that binds to B7 on APC that acts as costimulatory signals for T cell activation
b) CTLA-4 is a protein that binds to B7 on APC that acts as a suppressor signal for T cell activation
c) Both
d) None

10) Which of the cytokines function in an autocrine manner and induce T cell proliferation after engagement of TCR with antigens interaction and presence of secondary signal?
a) IL-1
b) IL-2
c) IL-3
d) IL-4

11) Cytokines such as IL-2, IFN-γ, and TNF-β, play an important role in cell-mediated cytotoxicity, and delayed hypersensitivity. 
Which of the following subset of T helper cells are involved in the process?
a) T helper 1 CD4+
b) T helper 2 CD4+
c) T helper 1 CD8+
d) T helper 2 CD8+

12) Cytokines such as IL-4, IL-5, IL-6 & IL-10 play an important role in B cell activation and humoral immune response
a) T helper 1 CD4+
b) T helper 2 CD4+
c) T helper 1 CD8+
d) T helper 2 CD8+

13) The regulatory or suppressor T cells express the specific cell surface marker for its function. It is
a) CD4+ CD25+
b) CD4+ CD25-
c) CD4 - CD8 - CD25 +
d) CD4 + CD8 + CD25 +

14) The activated T cells undergo activation-induced cell death (AICD). 
Which of the following is the effector molecule that is a response for AICD?
a) IL-2
b) Fas/Fas ligand
c) IL-4
d) INF-γ

15) T-cell receptor engagement with antigenic peptide MHC may induce T cell activation or the clonal anergy. 
Which of the following interaction favors T cell activation?
a) Fas/Fas ligand
b) B-7 & CTLA-4 interaction
c) B-7 & CD28 interaction
d) B-7 & CD 8 interaction

Multiple Choice Answers:
1-c) Bone marrow
2-d) None of the above
3-b) CD44
4-d) commit T cells for CD4 or CD8 positive T cells
5-d) All of the above
6-c) Both A and B
7-d) All of the above
8-a) Lck
9-c) Both
10-b) IL-2
11- a) T helper 1 CD4+
12-b) T helper 2 CD4+
13- a) CD4+ CD25+
14-b) Fas/Fas ligand
15-b) B-7 & CTLA-4 interaction