BIOCHEMISTRY, BIOMEDICINE & PHARMACEUTICS

Multiple Choice Question on T cell Development, Differentiation, and Activation 1) T cells (T lymphocytes) are crucial in the recognition of antigens presented by self-MHC. The T cell progenitors undergo proliferation and differentiation in the thymus and form a mature T cell.  Which of the following organ is the origin of T cell progenitors ? a) Thymus b) Hepatocytes c) Bone marrow d) None of the above 2) What is the characteristic feature of progenitor T cells that have migrated to the thymus? a) They express T cell receptor/CD3 complex b) They express CD28 cell adhesion molecule c) They express CD4 or CD8 co-receptor d) None of the above 3) Which of the following cell adhesion molecule is present in the T cell progenitors required for homing these cells into the thymus? a)CD25 b) CD44 c) IL-2 d) CTLA-4 4) Pre- T cell receptor complex consists of the β chain of TCR & CD3 molecules that are formed during the proliferation of T cells.   Th...

                 MCQ on Immunodeficiency diseases/Immunodeficiency disorders Immunodeficiency diseases or disorders: It refers to the disorders characterized by a weakened or impaired immune system. These disorders leads an individual more susceptible to infections and other diseases because their immune system is unable to adequately defend against microbial infections. 1. Which of the following is a rare and severe form of immunodeficiency where individuals lack T cells and B cells? a) DiGeorge Syndrome b) Wiskott-Aldrich Syndrome (WAS) c) Severe Combined Immunodeficiency (SCID)     d) Common Variable Immunodeficiency (CVID) 2. Wiskott-Aldrich Syndrome (WAS, an X-linked disorder) is associated with which of the following condition? a) Hypertension    b) Asthma  c) Diabetes mellitus  d) Eczema       3. Which of the following is not a primary immunodeficiency disorder?...