MCQ on Immunodeficiency diseases/Immunodeficiency disorders
Immunodeficiency diseases or disorders:It refers to the disorders characterized by a weakened or impaired immune system. These disorders leads an individual more susceptible to infections and other diseases because their immune system is unable to adequately defend against microbial infections.
1. Which of the following is a rare and severe form of immunodeficiency where individuals lack T cells and B cells?
a) DiGeorge Syndrome
b) Wiskott-Aldrich Syndrome (WAS)
c) Severe Combined Immunodeficiency (SCID)
d) Common Variable Immunodeficiency (CVID)
2. Wiskott-Aldrich Syndrome (WAS, an X-linked disorder) is associated with which of the following condition?
a) Hypertension
a) Hypertension
b) Asthma
c) Diabetes mellitus
d) Eczema
3. Which of the following is not a primary immunodeficiency disorder?
a) Acquired Immunodeficiency Syndrome (AIDS)
b) Common Variable Immunodeficiency (CVID)
c) DiGeorge syndrome (thymic hypoplasia)
d) Wiskott-Aldrich Syndrome (WAS)
4. All of the following are the humoral immunodeficiencies, except
a) Immunodeficiencies with hyper IgM
b) X-Linked Agammaglobulinemia (XLA)
c) DiGeorge syndrome (thymic hypoplasia)
d) Selective immunoglobulin deficiencies (IgM, IgG, IgA)
5. Which of the following immunodeficiency is only seen in infant males leading to recurrent pyogenic bacterial infection?
a) Severe Combined Immunodeficiency (SCID)
b) Multiple sclerosis
c) X-Linked Agammaglobulinemia (XLA)
d) Diabetes mellitus
6. Which of the following best describes the Shwachman-Diamond syndrome/disorder?
a) The genetic disorder in which phagocytes are unable to kill certain bacteria and fungi (chronic granulomatous syndrome)
b) The disorder of pancreas and bone marrow
c) A rare immunodeficiency where individuals lack T cells and B cells (combined immunodeficiency)
d) A rare disorder with recurrent skin staphylococcal infections and pulmonary infections (elevated IgE levels in childhood)
7. Chronic mucocutaneous candidiasis is caused by which of the following type of immunodeficiency/disorder?
a) Cellular immunodeficiency
b) Humoral or B cell deficiency
c) Phagocytosis disorder
d) Complement component (C3, C6, C7, C80 disorder
8. Which of the following is the correct statement regarding the Nezelof's syndrome (combined immunodeficiency with immunoglobulin) ?
a) The disorder of pancreas and bone marrow
b) Abnormal immunological response to Candida albicans
c) Disorder with pigmentation of skin, hair and eyes is decreased with recurrent pyogenic infections
d) T cell and B cell deficiency with recurrent bacterial, viral, fungal and protozoal infections
9. Which of the following gram positive bacteria are the common bacteria responsible for eczema and pneumonia in individuals with Hyper- IgE syndrome (high IgE level) ?
a) Bacillus cereus and Clostridium perfringens
b) Actinomyces israelii and Nocardia asteroides
c) Staphylococcus aureus and Streptococcus pyogenes
d) None of the above
10. What are the possible factors for secondary immunodeficiency?
a) Cytotoxic drugs
b) Metabolic disorders
c) Malnutrition
d) All of the above
Answers:
1. c) Severe Combined Immunodeficiency (SCID)
2. d) Eczema, it is a skin disorder
3. a) Acquired Immunodeficiency Syndrome (AIDS), it is a secondary immunodeficiency because the immune system is impaired or weakened by other disease or treatment.
4. c) DiGeorge syndrome (thymic hypoplasia), it is a cellular immunodeficiency that results in Underdevelopment of the thymus and parathyroid glands due to a chromosomal disorder where 22 chromosome is missing.
5. c) X-Linked Agammaglobulinemia (XLA)
6. b) The disorder of pancreas and bone marrow
7. a) Cellular immunodeficiency, cell mediated immunity to Candida albicans is deficient
8. d) T cell and B cell deficiency with recurrent bacterial, viral, fungal and protozoal infections
9. c) Staphylococcus aureus and Streptococcus pyogenes
10. d) All of the above
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