Pharmacological agents that directly or indirectly inhibit purine and pyrimidine synthesis have been used as anti-bacterial agents and anti-tumor drugs. These classes of drugs inhibit purine / pyrimidine synthesis and availability in the cells thereby decreasing cell replication. The inhibitors of the purine degradation pathway are used for the treatment of Gout. The pharmacological agents / inhibitors are as follows: i) Fluorouracil (anti-tumor agents) ii) Sulfonamides and Trimethoprim (antibacterial agents) iii) Allopurinol (for 'Gout' management) Anti-tumor agents: Fluorouracil is a mechanism-based drug that inhibits the enzyme Thymidylate synthetase (TS). Thymidylate synthetase is an enzyme that catalyzes the synthesis of deoxyuridine monophosphate to deoxythymidine monophosphate, a building block of DNA. The inhibitor of the enzyme led to decreased production of dTMP and reduced substrate for DNA replication and cell cycle. 5-Fluorouracil competes with uracil ...