Overview of the Topics Anticoagulant Drugs (Click Here) Thrombolytic Drugs Antiplatelet Drugs (Click Here) Multiple Choice Practice Questions (Click Here) Thrombolytic Drugs Thrombolytic/Fibrinolytic agents lyse the formed clots (thrombi) by catalyzing the activation of endogenous fibrinolytic protein (Plasminogen to Active Plasmin). The clinically important thrombolytics include streptokinase, urokinase, and other recombinant forms (Alteplase, Reteplase & Tenecteplase) Indication for Thrombolytics Used intravenously for short-term emergency management of - Acute Myocardial Infarction & recanalization of the thrombosed artery - Deep vein thrombosis - Pulmonary embolism - Stroke Mechanism of action - serves as a plasminogen activators - the first generation thrombolytics such as streptokinase (from bacteria- beta-hemolytic Streptococcus) acts on both bound and free plasminogen - Second generation thrombolytics such as Alteplase (tPA) mainly act on the fibr...