The surfactants are chemical substance that is capable of lowering surface tension. The lung surfactants contain a complex mixture of phospholipids, neutral lipids, and specific proteins. The lung surfactants are essential for normal lung function as it reduces surface tension at the air-liquid interface of alveolar spaces. Phosphatidylcholine is a major component of the surfactant comprising 90% of the lipids. Four specific surfactant proteins SP-A, SP-B, SP-C, SP-D. The synthesis and secretion of functional surfactants are confined to type II cells of the alveolar epithelium. The fundamental pathway for lung surfactant phospholipid synthesis, it's packaging into storage lamellar bodies (LB), secretion into the alveolar lining fluid and recycling back into ATII cells are well known. Bulk surfactant phospholipid synthesized at the ER is transported to LBs by a mechanism that may employ specific carrier proteins and/or traffic through the Golgi. During the processes of s...