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MCQs on Bilirubin Metabolism: Biochemistry

Multiple Choice Question on  Bilirubin Metabolism and Related Disorders 1) Bilirubin is generated from the catabolism (breakdown) of protoporphyrin IX through a microsomal enzyme in a two reaction step. In the first step, the tetrapyrrole ring is opened to produce biliverdin which is subsequently converted into bilirubin through further reduction. What are the enzymes responsible for these two steps ? a) Heme dehydrogenase and Bilirubin oxygenase b) Heme oxygenase and Biliverdin reductase c) Heme deoxygenase and Biliverdin reductase d) Heme oxygenase and Bilirubin reductase 2) Approximately 85% of the total bilirubin produced is derived from senescent red blood cells in the reticuloendothelial cells of the liver, spleen, and bone marrow.  The remaining 15% of bilirubin is produced from RBC precursor during ineffective erythropoiesis, myoglobin, cytochromes, and peroxidases.  The daily production of bilirubin is .................................. a) 500-1...