MCQ on Neisseria gonorrhoeae and Neisseria meningitidis

                Multiple Choice Question on Neisseria species (Gram-negative cocci)

1). All of the following statements are the cultural characteristics of gram-negative diplococci, EXCEPT
a) Grow in aerobic as well as anaerobic conditions
b) They are oxidase-positive
c) Proper growth on media containing heated blood
d) Grow well in the presence of 20 to 25 % CO2

2) All of the following infections are the common clinical manifestations caused by N. gonorrhoeae, EXCEPT
a) Genital gonorrhea in women
b) Pelvic inflammatory disease in men
c) Neonatal conjunctivitis
d) Pharyngitis

3) N.gonorrhoeae consists of conjugate plasmids that make the bacteria resistant to which of the following antibiotics?
d) Ketoconazole

4) All, except one, are the examples of protein present in the antigenic structure of Neisseria gonorrhoeae that helps the bacteria to invade a host cell
a) Por proteins
b) Rmp proteins
c) Opa proteins
d) IgM protease

5)Name the antimicrobial drug that is not added in the culture media for the growth and isolation of Neisseria gonorrhoeae
a) Penicillin
b) Vancomycin
c) Amphotericin
d) Colistin

6) Which statement is true about the Nucleic Acid Amplification Tests used for the direct detection of Neisseria gonorrhoeae in the genitourinary specimens?
a) The test has low sensitivity and specificity in symptomatic and high prevalence populations
b) The test has equal sensitivity and specificity as Neisseria gonorrhoeae in symptomatic and high prevalence populations
c) The test has high sensitivity and specificity in symptomatic and high prevalence populations
d) The test has high sensitivity and low specificity in symptomatic and high prevalence populations

7) Among the serogroups of Neisseria meningitidis given, which of these are the most important associated with meningococcal infection?
a) A, B, C, Y and W135
b) A, B, C, X, Y, and W135
c) A, B, C, X, Y, and W125
d) A, B, C, X and W135

8) The meningococcal infections are predominant in which of the following age group?
a) Infants only
b) Children and Young adults
c) Adults only
d) Children and Adults

9) What is the one effective method of treatment for primary stages of gonorrhoeal infections?
a) Vaccine
b) Use of condom
c) No treatment available
d) Antibiotics

10) Which of the following antigenic structure is considered the major virulence factor in the pathogenesis of Neisseria meningitidis?
a) Polysaccharide capsule
b) Pili
c) Porin
d) Opa protein

11) Which of the following component may not be required for the culture of blood specimens taken from the meningococcal infection patient?
a) Sodium sulfonate
b) Sodium gluconate
c) Sodium polyanethol sulfonate
d) Sodium polyascorbate

12) What serological test is used to measure the antibodies to meningococcal polysaccharides?
a) Latex agglutination test
b) Hemagglutination test
c) Latex and hemagglutination tests
d) None of the above

13) What is the drug of choice for the treatment of meningococcal disease?
a) Penicillin
b) Amphotericin
c) Methicillin
d) Penicillin G

14) Which of the following route is not the common route for the transfer and spread of N.gonorrhoea?
a) Through kissing and hugging
b) Sexual intercourse 
c) Infected mother to fetus
d) All of the above

15) Which of the following tests can be used to differentiate between Moraxella catarrhalis and saprophytic Neisseria spp from sputum specimens?
a) Oxidase
b) Butyrate esterase
c) Gram stain
d) Catalase

Multiple Choice Question Answers:

1-d)Grow well in the presence of 20 to 25 % CO2
2-b)Pelvic inflammatory disease in men
4-d)IgM protease
8-b) Children and Young adults
9-d) Antibiotics
10-a)Polysaccharide capsule
12 (c),
13 (d),
14-a)Through kissing and hugging
15-b) Butyrate esterase


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