MCQ on Neisseria gonorrhoeae and Neisseria meningitidis: Medical microbiology


              Multiple Choice Question on Neisseria species (Gram-negative cocci)

1). All of the following statements are the cultural characteristics of gram-negative diplococci, EXCEPT
a) Grow in aerobic as well as anaerobic conditions
b) Fastidious microorganism and require enriched media
c) Isolation on media containing heated blood
d) Grow well in the presence of 20 to 25 % CO2

2) All of the following infections are the common clinical manifestations caused by N. gonorrhoeae, EXCEPT
a) Genital gonorrhea in women
b) Pelvic inflammatory disease in men
c) Neonatal conjunctivitis
d) Pharyngitis

3) N.gonorrhoeae consists of conjugate plasmids that make the bacteria resistant to which of the following antibiotics?
d) Ketoconazole

4) All, except one, are the examples of protein present in the antigenic structure of Neisseria gonorrhoeae that helps the bacteria to invade a host cell
a) Por proteins
b) Rmp proteins
c) Opa proteins
d) IgM protease

5)Name the antimicrobial drug that is not added in the culture media for the inhibition of other bacteria and growth and isolation of Neisseria gonorrhoeae 
a) Penicillin
b) Vancomycin
c) Amphotericin
d) Colistin

6) Which statement is true about the Nucleic Acid Amplification Tests used for the direct detection of Neisseria gonorrhoeae in the genitourinary specimens?
a) The test has low sensitivity and specificity in symptomatic and high prevalence populations
b) The test has equal sensitivity and specificity as Neisseria gonorrhoeae in symptomatic and high prevalence populations
c) The test has high sensitivity and specificity in symptomatic and high prevalence populations
d) The test has high sensitivity and low specificity in symptomatic and high prevalence populations

7)There are various serogroups of Neisseria meningitidis.
Which of these are the most important associated with meningococcal infection?
a) A, B, C, Y and W135
b) A, B, C, X, Y, and W135
c) A, B, C, X, Y, and W125
d) A, B, C, X and W135

8) The meningococcal infections are predominant in which of the following age group?
a) Infants only
b) Children and Young adults
c) Adults only
d) Children and Adults

9) What is the one effective method of treatment for the primary stages of gonorrheal infections?
a) Vaccine
b) Use of condom
c) No treatment available
d) Antibiotics

10) Which of the following antigenic structure is considered the major virulence factor in the pathogenesis of Neisseria meningitidis?
a) Polysaccharide capsule
b) Pili
c) Porin
d) Opa protein

11) Which of the following component may not be required for the culture of blood specimens taken from the meningococcal infection patient?
a) Sodium sulfonate
b) Sodium gluconate
c) Sodium polyanethol sulfonate
d) Sodium polyascorbate

12) What serological test is used to measure the antibodies to meningococcal polysaccharides?
a) Latex agglutination test
b) Hemagglutination test
c) Latex and hemagglutination tests
d) None of the above

13) What is the drug of choice for the treatment of the meningococcal disease?
a) Penicillin
b) Amphotericin
c) Methicillin
d) Penicillin G

14) Which of the following route is not the common route for the transfer and spread of N.gonorrhoea?
a) Through kissing and hugging
b) Sexual intercourse 
c) Infected mother to fetus
d) All of the above

15) Which of the following tests can be used to differentiate between Moraxella catarrhalis and saprophytic Neisseria spp from sputum specimens?
a) Oxidase
b) Butyrate esterase
c) Gram stain
d) Catalase

16) Vertical transmission of gonococcal infection to neonates can occur during the delivery through an infected mother.
What is the most common type of infection seen in newborns?
a) Meningitis
b) Liver infection
c) Mastitis
d) Ocular infection

17) N.gonorrhoeae infection of the genitourinary tract can develop into a pelvic inflammatory disease in women.
What are the most common life-threatening infections that may occur due to the infection? 
Choose all the correct answers:
a) Infertility
b) Endometritis 
c) Ectopic pregnancy
d) Meningitis

18) All of the following statement is true for meningococcal disease, except?
a) Vaccine is available for children above 10 for the prevention of the disease
b) Immunocompromised patient that have HIV, or people with sickle cell anemia are susceptible 
c) Three serogroups of virus are most prevalent for the majority of the infection 
d) It is a rare disease but can be severe and fatal if contracted

19) Which of the following are commonly used specific tests for the identification of N. gonorrhea and N. meningitidis, Except?
a) Nucleic Acid Amplification Tests (NAATs)
b) Enzyme immunoassays for gonococcal antigen 
c) Rapid antigen detection by latex agglutination
d) Venereal disease laboratory test (VDRL)

20) Which of the following bacteria are the leading cause of meningitis around the world?
Select all the correct answers:
a) Neisseria meningitidis
b) Haemophilus influenzae
c) Group B Streptococcus
d) Coccidioides immitis 

Multiple Choice Question Answers:

1-d)Grow well in the presence of 20 to 25 % CO2.
Neisseria spp is a fastidious microorganism and grows well in selective media such as Thayer Martin media with 5-10 % of CO2 requirements.

2-b)Pelvic inflammatory disease in men
4-d)IgM protease
8-b) Children and Young adults
9-d) Antibiotics
10-a)Polysaccharide capsule
12 (c),
13 (d),
14-a)Through kissing and hugging
15-b) Butyrate esterase
16-d) Ocular infection
17-a), b), and c)
18- c) Three serogroups of virus are most prevalent for the majority of the infection. 
Four serogroups A, C, W, and Y consists of the major groups that cause meningococcal disease

19- d)  Venereal disease laboratory test (VDRL), is a screening test for Syphilis 

20- a) Neisseria meningitidis, b) Haemophilus influenzae and c) Group B Streptococcus
d) Coccidioides immitis is a fungi that causes fungal meningitis.


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