MCQ on Vaccines: Medical Microbiology

1) When was the smallpox virus first eradicated from the world?
a) 1990
b) 1960
c) 1970
d) 1980 

2) The vaccine consists of the Antigen as an important constituent, to avoid contamination and increase the immune response other components added during the manufacturing process of a vaccine are tiny amounts of an adjuvant, preservative, and stabilizer. Which of the following is Not the commonly used adjuvant present in a vaccine?
a) Formaldehyde 
b) Aluminum sulphate
c) Potassium aluminum sulfate
d) Aluminum hydroxide

3) Immunization is an important and effective way to protect humans from different types of infectious diseases. The two main types of immunization are active and passive immunization. All of the following statements are correct about the active and passive immunization process, Except?
a) Both can occur naturally as well as artificially
b) Active immunization is the inoculation of live, attenuated and dead pathogens
c) Both types of immunization may provide long term protection to the immune system  
d) Administration of preformed antibodies are the form of passive immunization

4) Which of the following statement is Incorrect about the vaccine development process?
a) It consists of a live attenuated or killed germ cells
b) Aluminum can be used as an adjuvant in a vaccine
c) Animal trials are not necessary for every vaccine before going to the human trial 
d) Normal vaccine production can take up to 10 to 15 years

5) Which of the following is the Not the example of a live attenuated vaccine?
a) Diphtheria vaccine 
b) Measles vaccine
c) BCG vaccine
d) Oral polio vaccine

6) Subunit vaccine is all, Except
a) A whole purified virus 
b) A purified part or pieces of the antigen
c) An expensive type of vaccine
d) A Hepatitis-B vaccine

7) WHO/CDC recommends vaccination of children under six years of age to protect themselves from several infectious diseases. The following are the important vaccines administered in childhood, Except?
a) Dtap (diphtheria, tetanus, and pertussis)
b) Polio
c) MMR
d) Hepatitis A and B
e) Rabies 

8) The first scientifically approved vaccine was................
a) Oral polio vaccine
b) Smallpox vaccine >
c) MMR vaccine (measles, mumps, and rubella)
d) Tetanus vaccine

9) Which of the following is Not the most common type of vaccine? Select the correct answers from the options given below
a) Live attenuated     
b) Killed vaccine   
c) Conjugated vaccine    
d) Subunit vaccine    
e) Toxoid vaccine     

10) Which of the following statement is not true about the Live attenuated vaccine?
a) It is prepared using whole weakened living bacteria or virus
b) It can generate a long-term immune response in an individual usually with a single dose of vaccine
c) Measles, MMR and oral polio vaccine are live attenuated vaccines
d) It is stable at normal room temperature 

11) Which of the following is not true about the important characteristics of the effective vaccine?
a) It must be safe and easy to use with low side effects in humans
b) It must provide immunity to at least 15% of the population 
c) It must be available at low cost
d) It must provide long-lasting immunity

12) Numerous biotechnology industries are fast-tracking development of vaccines for COVID-19. Which of the following statement is true regarding the stages of vaccine development?
a) Animal studies are performed to show the safety and effectiveness of vaccine candidate
b) Phase 1/2 clinical studies are conducted to show the safety of the candidate vaccine in humans
c) Phase 3 clinical studies are conducted to show the efficacy of the candidate vaccine in humans
d) All of the above 

13) Before the invention of the Polio vaccine in 1955 Poliomyelitis was a serious viral infection, thousands of children got infected with serious illness including the paralysis of the neurons and the number of children who died around the world. Which of the following statement is not true about the polio vaccine?
a) It is always present in the form of killed or inactivated vaccine 
b) Outbreaks of the virus still occur mostly in underdeveloped countries
c) The doses of vaccines must be given to children under 6 years of age
d) It is present in two forms, oral polio vaccine and inactivated polio vaccine
e) Adults traveling to polio risk region should get vaccinated
14) There are numerous cases of influenza/flu caused by influenza virus each year around the world, although symptoms of the flu are usually mild, a number of people are hospitalized with serious illness and thousands of deaths are recorded every year. The most important preventive measure through which a person can prevent the flu is vaccination, which of the following statement is Not true about influenza/flu vaccine? Select all the correct answers
a) In the USA the vaccine is recommended from 6 months of age for two times every year 
b) Flu vaccines may contain killed viruses or weakened viruses 
c) Flu vaccines are mainly available in two forms, shots and nasal spray 
d) The influenza virus is a highly mutating virus, therefore annual vaccination is recommended 
e) The immune system gets activated 2-3 weeks after an individual is vaccinated 

15) Vaccination at an early age can protect humans from several viral diseases, including life-threatening infections like smallpox and polio. Which of the following diseases have vaccines available? Select all the correct answers from the options given below
a) Polio 
c) Diphtheria   
d) COVID-19
e) Ebola
f) Chickenpox

1. d)
2. a)
3. c)
4. c)
5. a)
6. a)
7. e)
8. b)
9. a), b), c), d), e)
10. d)
11. b)
12. d)
13. a)
14. a), b), c), d), e)
15. a), c), f)