Overview of the Topics Anticoagulant Drugs (Click Here) Thrombolytic Drugs (Click Here) Antiplatelet Drugs (Click Here) Multiple Choice Practice Questions (Click Here) Antiplatelet drugs - Platelet aggregation occurs in response to vascular injury - The aggregation of platelets in the coronary artery can lead to the development of atherosclerotic plaque - It may precipitate coronary vasospasm, myocardial infarction, and stroke Clinical Indication - Prophylaxis of arterial thrombosis - Therapeutic management of myocardial infarction and stroke - Should be infused within 2 hours of myocardial infarction or stroke for significant benefit Clinically Important Antiplatelet Agents - Thromboxane A2 pathway, ADP pathway & GPIIb/IIIa receptors are the therapeutic targets to prevent platelet activation and aggregation. The drugs include - Aspirin - Clopidogrel - Abciximab Aspirin - Aspirin inhibits platelet aggregation and prolongs bleeding time - Aspirin irreversib...