Multiple Choice Questions and Answers with explanation on MHC Structure, Gene arrangement & Function 1) Polymorphisms in the Major histocompatibility Complex (MHC) genes are linked to an elevated vulnerability to specific diseases, with one such allele being B47, which is correlated with susceptibility to .................................. a) Ankylosis spondylitis b) Reactive arthritis c) Reiter’s syndrome d) All of the above 2) Hereditary hemochromatosis is a disorder characterized by iron overload liver and other tissues. Which of the MHC allele is associated with the highest relative risk for hereditary hemochromatosis? a) A13 / B14 co-incidence b) B12 / A3 co-incidence c) A3 / B14 co-incidence d) None of the above 3) Narcolepsy is a chronic neurological disorder that affects the brain's ability to control the sleep-wake cycle. Which of the following MHC allele is associated with it? a) Human leukocyte antigen (HLA) DR1 b) Human leukocyte antigen ...