Immunology: MHC Structure, Gene arrangement & Function: MCQ


Multiple Choice Questions MHC Structure, Gene arrangement & Function 

1) Major histocompatibility complex (MHC) gene polymorphism and alleles are associated with increased susceptibility of certain diseases. One of the allele, B47 which is associated with
a) Ankylosis spondylitis
b) Reactive arthritis
c) Reiter’s syndrome
d) All of the above

2) Hereditary hemochromatosis is a disorder characterized by iron overload liver and other tissues. Which of the MHC allele is associated with the highest relative risk for hereditary hemochromatosis?
a) A13/B14 co-incidence
b) B12/A3 co-incidence
c) A3/B14 co-incidence
d) None of the above

3) Narcolepsy is a chronic neurological disorder that affects brain ability to control the sleep-wake cycle. Which of the follow MHC allele is associated with it?
a) DR1
b) DR2
c) DR3
d) DR4

4) Systemic lupus erythematosus is an autoimmune disorder characterized by chronic and systemic inflammation due to loss of immune tolerance against nuclear autoantigen. The MHC allele associated with the susceptibility include
a) DP beta 1
b) DQ beta 1
c) DR beta 1
d) None of the above

5) Major Histocompatibility Complex (MHC-I) molecules are the cell surface proteins activates T cells and mediate effector T-cell function. Which of the following class of MHC molecules activate cytotoxic T cells?
a) MHC class I
b) MHC class II
c) MHC class III
d) All of the above

6) The MHC molecules are encoded by specific genes. Which of the following is an incorrect statement regarding MHC genes:
a) MHC class I proteins are encoded by B, C & A genes
b) MHC class II proteins are encoded by DP, DQ and DR genes
c) Both MHC class I and MHC class II genes are present in the same region of chromosome
d) MHC class I and MHC class II are encoded by genes located in the different region of chromosomes

7) The MHC proteins are highly polymorphic. The following factors contribute to the polymorphism, EXCEPT
a) MHC proteins are present in haplotypes
b) MHC is co-dominantly expressed
c) MHC genes are highly conserved
d) None of the above

8) Which of the following statement is FALSE regarding MHC proteins
a) MHC class I is a dimer consisting of two chains: one alpha chain (three subunits) and b2 microglobulin chain expressed outside the cell membrane
b) MHC class I is a dimer consisting of two chains: an alpha and a beta-chain each consisting of two subunits expressed outside the cell membrane
c) Both of the above
d) None of the above

9) Beta2 microglobulin is a highly conserved subunit essential for expression of class I on the cell surface. Identify the correct statement regarding Beta2 microglobulin gene
a) It is located on the same chromosome as B, C, A genes
b) It is located in a different chromosomal location than B, C, and A genes
c) It is a part of MHC I gene cluster
d) None of the above

10) The following is the characteristic feature of peptide binding cleft for MHC class I proteins
a) It consists of alpha 1 and alpha 2 subunits
b) The pocket can bind to 8-10 amino acid peptide
c) It is a close-ended pocket
d) All of the above

11) The anchor residues are mostly present in the c-terminal end of the peptide and bind to the amino acid residue on the peptide-binding cleft. The anchor residues are
a) Acidic amino acid
b) Basic amino acids
c) Hydrophobic amino acids
d) None of Above

12) The CD8 cell surface protein of T cells interact with …………….. of MHC class I molecules.
a) alpha-1 subunit
b) alpha-2 subunit
c) alpha-3 subunit
d) beta2- microglobulin

13) Interferon-gamma is a cytokine that induces the expression of
a) MHC class I
b) MHC class II
c) Both of Above
d) None of Above
14) The MHC expression is decreased by infection of some viruses namely
a) Human Cytomegalovirus
b) Hepatitis Virus
c) Adenovirus 12
d) All of the above
15) Many viruses produce a protein immunoevasin that interferes with antigen presentation by MHC class I molecules. The immunoevasin interfere MHC presentation by
a) Block peptide transport to TAP
b) Inhibiting E3 ubiquitin ligase activity
c) Block tapasin function
d) All of the above

16) The antigen recognition by T cell depends on the presence of specific MHC molecules in the antigen-presenting cell which is known as
a) MHC-recognition
b) MHC-restriction
c) MHC-processing
d) MHC-signaling

17) Which of the following gene is not the part of MHC class I gene cluster
a) TAP gene
b) Tapasin gene
c) Proteasome LMP gene
d) TNF gene

18) MHC molecules are necessary for T cell response. Which of the following function is mediated by MHC-T cell interaction?
a) Immune Tolerance
b) Cytotoxicity
c) B-cell activation
d) All of the above

19) The following is the characteristic feature of peptide binding cleft for MHC class II proteins
a) It is formed by alpha1 and beta1 interaction
b) The pocket binds to 13-18 amino acids
c) MHC-II has open-ended peptide binding cleft
d) All of the above

20) The CD4 protein of T helper cells binds and stabilizes the MHC class II/peptide structure. The subunit that interacts with CD4 cell surface protein is
a) alpha1 and beta1 subunit
b) alpha2 and beta2 subunits
c) alpha1 and alpha2 subunits
d) beta1 and beta2 subunits

21) Bare lymphocytes are the genetic disorder caused by a lack of class II molecules on the cell surface. This is associated with
a) Mutation of the gene encoding MHC class II proteins
b) The mutation that leads to MHC folding
c) Mutation of transcription factor protein (CIITA) required for expression of MHC class II proteins
d) None of the above
Multiple Choice Answers Review
1-d) All of the above
2-c) A3/B14 co-incidence
3-c) DR3
4-c) DR beta 1
5-a) MHC class I
6-c) Both MHC class I and MHC class II genes are present in the same region of chromosome 7-c) MHC genes are highly conserved
8-d) None of the above
9-b) It is located in a different chromosomal location than B, C, and A genes
10-d) All of the above
11-c) Hydrophobic amino acids
12-c) alpha-3 subunit
13-c) Both of Above
14-d) All of the above
15-d) All of the above
16-b) MHC-restriction
17- d) TNF gene
18-d) All of the above
19-d) All of the above
20- d) beta1 and beta2 subunits
21-c) Mutation of transcription factor protein (CIITA) required for expression of MHC class II proteins

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