Antimicrobials: Cell wall synthesis and protein synthesis inhibitorsMultiple Choice Questions
1) Which of the following combination is correct?
a) Penicillin: inhibition of cell wall synthesisb) Cephalosporin: inhibition of protein synthesis
c) Aminoglycoside: inhibition of cell wall synthesis
d) Fluoroquinolones: inhibition of cell wall synthesis
2) What is a common feature among the following group of antibiotics like Penicillin, Cephalosporins, Carbapenems, and Monobactams?
a) They all bind penicillin-binding protein-1 and inhibit their transpeptidase activityb) They all have a β-lactam ring as a part of their biological interaction
c) None of them can penetrate the central nervous system
d) All of the above
3) Amoxycillin is similar to Ampicillin in different respects except in ………………
a) Antibacterial spectrumb) Penicillinase resistance
c) Hypersensitivity reaction
d) Oral absorption
4)All of the ffollowing statements about Clavulanic acid, Sulbactam and Tazobactam are true, except:
a) Antibiotic activity of beta-lactamases is inhibited by beta-lactamasesb) Inhibits beta-lactamases and can be administered with penicillinase sensitive penicillins
c) Co-administered with carbapenems to block carbapenemase inactivation
d) Typically co-administered with the cephamycin
5) The following cephalosporin is associated with bleeding complications
a) Cefotaximeb) Cefuroxime
c) Cefotetan
d) Cefazolin
6) A 26-year-old male returns home from a holiday and complains of three days of dysuria and a purulent urethral discharge. He is diagnosed to be a case of gonorrhea.
Which of the following is the appropriate treatment?
a) Ceftriaxone IMb) Streptomycin
c) Gentamicin
d) Vancomycin IV
7) Redman syndrome is toxicity associated with
a) Amoxicillinb) Daptomycin
c) Linezolid
d) Vancomycin
8) Cilastatin is given along with Imipenem for the following reason:
a) Inhibition of beta-lactamases thus preventing inactivation of Imipenemb) Blocking of bacterial transpeptidase and preventing degradation of Imipenem
c) Decreasing hydrolysis of Imipenem
d) Inhibition of renal tubular dipeptidase thus preventing hydrolysis of Imipenem by renal tubular dipeptidase
9) A 72 years old man who was administered Penicillin intravenously developed generalized urticaria, swelling of lips, hypotension, and bronchospasm within 5 minutes. The first choice of treatment is to administer
a) High dose hydrocortisone tabletb) Chlorpheniramine injection
c) Adrenaline injection
d) Isoprenaline injection
10) Followings are the penicillinase-resistant penicillin, except:
a) Carbenicillinb) Methicillin
c) Nafcillin
d) Cloxacillin
11) Which of the following antibiotics acts as a protein synthesis inhibitor?
a) Erythromycin, Chloramphenicolb) Vancomycin, Cephamycin
c) Gentamicin, Tetracycline
d) Options a and c
e) Options b and c
12) Ototoxicity, vestibulo-toxic impairment, and nephrotoxicity are seen as major adverse effects of
a) Aminoglycosidesb) Macrolides
c) Fluoroquinolones
d) All of the above
13) Gray baby syndrome in neonates can be caused by
a) Penicillinb) Chloramphenicol
c) Quinolones
d) Sulphonamides
14) Fanconi syndrome can be caused by
a) Tetracyclineb) Quinolones
c) Sulphonamide
d) Penicillin
15) Following cephalosporins can cross the blood-brain barrier and therefore can be used in the treatment of meningitis except
a) Ceftazidimeb) Ceftriaxone
c) Cefotaxime
d) Cefixime
16) Random use of broad-spectrum antibiotics is contraindicated.
They............................................................................................
a) Are extremely nephrotoxicb) Can produce dependency and psychogenic symptoms
c) Can induce anaphylactoid reactions
d) Can interfere with indigenous microbiota
17) All of the followings are the adverse effects of tetracycline, except:
a) Ototoxicityb) Phototoxicity
c) Fatal hepatotoxicity
d) Yellow discoloration of teeth
18) Which of the following group of antibiotics show bacteriostatic action?
a) Fluoroquinolonesb) Aminoglycosides
c) Macrolides
d) Monobactams
19) Which of the following group of antibiotics in accordance with the structure and mode of action of penicillin?
a) Chloramphenicolb) Polymyxins
c) Cycloserines
d) Cephalosporins
Answers:
1-a) Penicillin: inhibition of cell wall synthesis
2-b) They all have a β-lactam ring as a part of their biological interaction
3-d) Oral absorption
4-b) Inhibits beta-lactamases and can be administered with penicillinase sensitive penicillins
5-c) Cefotetan
6-a) Ceftriaxone IM
7-d) Vancomycin
8-d) Inhibition of renal tubular dipeptidase thus preventing hydrolysis of Imipenem by renal tubular dipeptidase
9-b) Chlorpheniramine injection
10-a) Carbenicillin
11-d) Options a and c
12-a) Aminoglycosides
13-b) Chloramphenicol
14-a) Tetracycline
15-d) Cefixime
16-d) Can interfere with indigenous microbiota
17-a) Ototoxicity
18-c) Macrolides
19-d) Cephalosporins
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