Pharmacology: MCQ on Antimicrobial Agents-I

Antimicrobials: Cell wall synthesis and protein synthesis inhibitors

Multiple Choice Questions

1) Which of the following combination is correct?
a) Penicillin: inhibition of cell wall synthesis
b) Cephalosporin: inhibition of protein synthesis
c) Aminoglycoside: inhibition of cell wall synthesis
d) Fluoroquinolones: inhibition of cell wall synthesis

2) What is a common feature among the following group of antibiotics like Penicillin, Cephalosporins, Carbapenems, and Monobactams?
a) They all bind penicillin-binding protein-1 and inhibit their transpeptidase activity
b) They all have a β-lactam ring as a part of their biological interaction
c) None of them can penetrate to the central nervous system
d) All of the above

3) Amoxycillin is similar to Ampicillin in different respects except in ………………
a) Antibacterial spectrum
b) Penicillinase resistance
c) Hypersensitivity reaction
d) Oral absorption

4) Following statement about Clavulanic acid, Sulbactam and Tazobactam are true except:
a) Antibiotic activity of beta-lactamases is inhibited by beta-lactamases
b) Inhibits beta-lactamases and can be administered with penicillinase sensitive penicillins
c) Co-administered with carbapenems to block carbapenemase inactivation
d) Typically co-administered with the cephamycin

5) The following cephalosporin is associated with bleeding complications
a) Cefotaxime
b) Cefuroxime
c) Cefotetan
d) Cefazolin

6) A 26-year old male returns home from a holiday and complains of three days of dysuria and a purulent urethral discharge. He is diagnosed to be a case of gonorrhea. Which of the following is an appropriate treatment?
a) Ceftriaxone IM
b) Streptomycin
c) Gentamicin
d) Vancomycin IV

7) Redman syndrome is toxicity associated with
a) Amoxicillin
b) Daptomycin
c) Linezolid
d) Vancomycin

8) Cilastatin is given along with Imipenem for the following reason:
a) Inhibition of beta-lactamases thus preventing inactivation of Imipenem
b) Blocking of bacterial transpeptidase and preventing degradation of Imipenem
c) Decreasing hydrolysis of Imipenem
d) Inhibition of renal tubular dipeptidase thus preventing hydrolysis of Imipenem by renal tubular dipeptidase

9) A 72 years old man who was administered Penicillin intravenously developed generalized urticaria, swelling of lips, hypotension, and bronchospasm within 5 minutes. The first choice of treatment is to administer
a) High dose hydrocortisone tablet
b) Chlorpheniramine injection
c) Adrenaline injection
d) Isoprenaline injection

10) Followings are the penicillinase-resistant penicillin except:
a) Carbenicillin
b) Methicillin
c) Nafcillin
d) Cloxacillin

11) Which of the following antibiotic acts as a protein synthesis inhibitor?
a) Erythromycin, Chloramphenicol
b) Vancomycin, Cephamycin
c) Gentamicin, Tetracycline
d) Options a and c
e) Options b and c

12) Ototoxicity, vestibulo-toxic impairment, and nephrotoxicity are seen as major adverse effects of
a) Aminoglycosides
b) Macrolides
c) Fluoroquinolones
d) All of the above

13) Gray baby syndrome in neonates can be caused by
a) Penicillin
b) Chloramphenicol
c) Quinolones
d) Sulphonamides

14) Fanconi syndrome can be caused by
a) Tetracycline
b) Quinolones
c) Sulphonamide
d) Penicillin

15) Following cephalosporins can cross the blood-brain barrier and therefore can be used in the treatment of meningitis except
a) Ceftazidime
b) Ceftriaxone
c) Cefotaxime
d) Cefixime

16) Random use of broad-spectrum antibiotic is contraindicated. They
a) Are extremely nephrotoxic
b) Can produce dependency and psychogenic symptoms
c) Can induce anaphylactoid reactions
d) Can interfere with indigenous microbiota

17) All of the followings are the adverse effects of tetracycline except:
a) Ototoxicity
b) Phototoxicity
c) Fatal hepatotoxicity
d) Yellow discoloration of teeth

18) Which of the following group of antibiotics show bacteriostatic action?
a) Fluoroquinolones
b) Aminoglycosides
c) Macrolides
d) Monobactams

19) Which of the following group of antibiotics in accordance with structure and mode of action to penicillin?
a) Chloramphenicol
b) Polymyxins
c) Cycloserines
d) Cephalosporins

1-a) Penicillin: inhibition of cell wall synthesis 

2-b) They all have a β-lactam ring as a part of their biological interaction

3-d) Oral absorption

4-b) Inhibits beta-lactamases and can be administered with penicillinase sensitive penicillins

5-c) Cefotetan

6-a) Ceftriaxone IM

7-d) Vancomycin

8-d) Inhibition of renal tubular dipeptidase thus preventing hydrolysis of Imipenem by renal tubular dipeptidase

9-b) Chlorpheniramine injection

10-a) Carbenicillin

11-d) Options a and c

12-a) Aminoglycosides

13-b) Chloramphenicol 

14-a) Tetracycline

15-d) Cefixime

16-d) Can interfere with indigenous microbiota

17-a) Ototoxicity

18-c) Macrolides

19-d) Cephalosporins