BIOCHEMISTRY, BIOMEDICINE & PHARMACEUTICS

                      Multiple Choice Question on Lipid Metabolism ( Cholesterol, Triglycerides, and                               Other Lipids ) 1) The cholesterol serves as the precursor for the following biosynthetic pathways,  EXCEPT a) Bile acid synthesis b) Steroid hormone synthesis c) Aldosterone synthesis d) Thyroid hormone synthesis 2) Which of the following lipids act as lungs surfactants? a) Phosphatidylcholine b) Phosphatidylethanolamine c) Ceramide d) Phosphatidylinositol 3) Identify the simple lipid from the following? a) Lecithin b) Fatty acid c) Triacylglycerol d) Steroids 4) All of the following are complex lipids, Except? a) Phosphatidic acid b) Cerebroside c) Cardiolipin d) Cholesterol 5) Which of the following is an essential fatty acid? a) Linolenic acid b) Arachidonic acid c) Oleic acid d) Palmitic...

                                     Multiple Choice Questions on Lipid Digestion and Absorption 1) Where does the emulsification of lipids primarily occur in the digestive system? a) Gallbladder b) Liver c) Small intestine d) Stomach 2) What is the enzyme responsible for the breakdown of triglycerides into fatty acids and mono-acylglycerol in the intestine? a) Pancreatic lipase b) Lipoprotein lipase c) Hormone-sensitive lipase d) Phospholipase 3) What is the function of bile salt in lipid digestion and absorption? a) Activator of lipase b) Emulsifier c) Co-factor for cholesteryl esterase d) Inhibitor of lipid absorption 4) What is the precursor for bile salt synthesis? a) Fatty acid b) Glucose c) Cholesterol d) Glycerol 5) The anti-obesity drug Orlistat inhibits a) Pancreatic lipase b) Lipoprotein lipase c) Hormone-sensitive lipase d) Phospholipase 6) Which of the following class ...

                 Multiple Choice Question on Lipid and Lipoprotein Metabolism 1) A child was presented with diarrhea and failure to thrive. The clinical and biochemical investigation showed fat malabsorption, spinocerebellar degeneration, pigmented retinopathy, and acanthocytosis. develop. He had decreased night and color vision, followed by daytime visual acuity reductions. The blood chemistry profile showed extremely low plasma cholesterol and triglyceride levels with no detectable chylomicrons VLDL, LDL, or apoB.  The genetic analysis showed that the disease was inherited in an autosomal recessive manner. Identify the probable cause from the following: a) Mutation in the gene that codes for ApoB b) Mutation in the gene that codes for MTP c) Mutation in the gene that codes for ApoC-II d) Mutation in the gene that codes  for CEPT 2) The biochemical analysis of plasma from a patient with pancreatitis showed hypertriglyceridemia wit...

Multiple Choice Question on Fatty Acid Synthesis and Breakdown (beta-oxidation) 1) Free fatty acids in the plasma..................................... a) Circulate in the unbound state b) Bind to lipoproteins and circulated c) Bind to albumin and circulated d) Bind to a fatty acid-binding protein and circulated 2) In what compartment does the de novo fatty acid synthesis occur? a) Mitochondria b) Peroxisome c) Endoplasmic reticulum d) Cytosol 3) What is the precursor for fatty acid synthesis? a) Acetyl CoA b) Propionyl CoA c) Succinyl CoA d) Acetoacetyl CoA 4) The conversion of acetyl CoA to malonyl CoA is the rate-limiting step in fatty acid synthesis.  Which of the following enzyme catalyzes the above-mentioned reaction ? a) Acetyl CoA carboxylase b) Malonyl CoA synthetase c) Acetyl CoA decarboxylase d) Malonyl CoA synthase 5) The acetyl CoA is produced in the mitochondria and must be transported into the cytosol for the synthesis of fatty acids....