BIOCHEMISTRY, BIOMEDICINE & PHARMACEUTICS

Multiple Choice Question on Classification, Pathogenesis, and Diagnosis of Anemia 1) Anemia is a reduction of total circulating red cell mass below the normal limits. The classical symptoms include palpitation, dizziness, angina, pallor of skin and nails, weakness, etc.  Which of the following laboratory parameter is used to classify anemia into microcytic, normocytic, or macrocytic? a) Mean Corpuscular Volume b) Mean Corpuscular Hemoglobin c) Mean Corpuscular Hemoglobin Concentration  d) Red Cell Distribution Width 2) Based on the size of the red blood cells, microcytic anemia is defined when the mean corpuscular volume (MCV) is ................................... a) Less than 80 fL / cell b) Less than 120 fL / cell c) Less than 160 fL / cell d) Less than 200 fL / cell 3) Which of the following condition is not associated with microcytic anemia? a) Iron Deficiency Anemia  b) Aplastic Anemia  c) Sieroblastic Anemia  d) Thalassemia  4) Identify the patholog...

Q) Which of the following is a FALSE statement about the fate of the glycolytic pathway in erythrocytes? a) Glycolysis is the sole source of ATP (adenosine triphosphate) in erythrocytes. b) Deficiency of pyruvate kinase leads to hemolytic anemia. c) Pyruvate generated during glycolysis is converted to lactate. d) Pyruvate generated during glycolysis is converted to acetyl CoA and enters the TCA cycle (tricarboxylic acid cycle) in mitochondria. (Correct Answer: Please find it at the end of this text ) The objective of the MCQ above is to discuss - Shape and morphology of   Red blood cell - The fate of glucose in red blood cells - Metabolic control of glucose metabolism Red blood cells are bone marrow-derived non-dividing cells that contain hemoglobin ( 95% of intracellular protein ) and help to transport oxygen from the lungs to peripheral tissue.  The RBCs help in the disposal of carbon dioxide and a proton from the peripheral tissue, they are biconcave in the s...