Case Presentation A 62-year-old man with a 10-year history of type 2 diabetes mellitus visited the hospital with complaints of swelling in his lower extremities. The patients' had a co-incidence of diabetes mellitus and hypertension. The clinical laboratory report showed the following observations: Biochemical Parameters Results Serum Glucose 250 mg/dL Serum Albumin 2.5g/dL Serum Creatinine 1.5 mg/dL Blood Urea itrogen 25mg/dL Serum Sodium 130 mEq/L Serum Potassium 4.3 mEq/L Serum Total Cholesterol 275 mg/dL Serum Anti-ANA antibodies Negative Serum Rheumatoid factors Negative Serum Cryoglobulins Negative Urine examinations Urinary proteins: 5.0 gm/dL Urinary glucose: ++ Provisional diagnosis: Diabetic kidney disease with hypoalbuminemia, massive protein loss( nephrotic syndrome), hypercholesterolemia. Nephroti...