Lipid Metabolism: MCQ on Fatty Acid Synthesis and Breakdown

Multiple Choice Question on Fatty Acid Synthesis and Breakdown


1) Free fatty acids in the plasma
a) Circulate in the unbound state
b) Bind to lipoproteins and circulated
c) Bind to albumin and circulated
d) Bind to a fatty acid binding protein and circulated

2) In what compartment does the de novo fatty acid synthesis occur?
a) Mitochondria
b) Peroxiosome
c) Endoplasmic reticulum
d) Cytosol

3) What is the precursor for fatty acid synthesis?
a) Acetyl CoA
b) Propionyl CoA
c) Succinyl CoA
d) Acetoacetyl CoA

4) The conversion of acetyl CoA to malonyl CoA is the rate-limiting step in the fatty acid synthesis. Which of the following enzyme catalyzes the above-mentioned reaction?
a) Acetyl CoA carboxylase
b) Malonyl CoA synthetase
c) Acetyl CoA decarboxylase
d) Malonyl CoA synthase

5) The acetyl CoA is produced in the mitochondria and must be transported into the cytosol for synthesis of fatty acid. Which of the following is true regarding its transport?
a) Acetyl CoA is diffused from the mitochondrial membrane
b) Acetyl CoA is transported by its specific transporter protein
c) Acetyl CoA is converted into pyruvate, enters into the cytosol and acetyl CoA is regenerated
d) Acetyl CoA is converted into citrate, enters into the cytosol and acetyl CoA is regenerated.

6) What is the allosteric regulator of acetyl CoA carboxylase?
a) Fatty acid
b) ATP
c) Citrate
d) Acetyl CoA

7) Which of the following event inactivates acetyl CoA carboxylase?
a) ADP-Ribosylation
b) Glycosylation
c) Phosphorylation
d) Farnesylation

8) Which of the following is not a positive regulator of acetyl CoA carboxylase
a) Excess calories
b) Insulin
c) Citrate
d) Long chain fatty acid

9) Which of the following enzyme statement is not true regarding fatty acid synthase?
a) Fatty acid synthase is a multifunctional enzyme
b) Fatty acid synthase is active as a dimer
c) Fatty acid synthase is activated by high-calorie food
d) Fatty acid synthase complex is inhibited by its phosphorylation

10) What form of energy is required for fatty acid biosynthesis?
a) ATP
b) NADH
c) NADPH
d) FADH2

11) What is the source of NADPH required for fatty acid synthesis?
a) Pentose phosphate pathway
b) Malic enzyme
c) Both
d) None