MCQs on Drugs targeting Autonomic Nervous System (Cholinergic, Muscarinic, Adrenergic Receptor)

Drugs targeting Autonomic Nervous System (Cholinergic, Muscarinic, Adrenergic receptor(Multiple Choice Questions)

1) Indirect-acting cholinomimetic agent acts via.................................................................?

a) Stimulation of action of acetylcholinesterase
b) Binds to and activate muscarinic and nicotinic receptors
c) Inhibition of hydrolysis of endogenous acetylcholine
d) Release of acetylcholine from the storage site

2) All of the followings are reversible indirectly acting cholinomimetics, except:

a) Physostigmine
b) Echothiophate
c) Edrophonium
d) Neostigmine

3) The drug used in the diagnosis of myasthenia gravis is …………………........?

a) Edrophonium
b) Pyridostigmine
c) Neostigmine
d) Ambenonium

4) Which of the following cholinomimetic drug is used for the treatment of craving reduction in nicotine addiction?

a)  Bupropion
b) Cevimeline
c)Varenicline
d) Galantamine

5) Stimulation of which subtype of the muscarinic cholinergic receptor causes miosis?

a) M1
b) M2
c) M4
d) M3
e) M5

6) The drug of choice in the management of atropine poisoning is ……………………........?

a) Edrophonium
b) Physostigmine
c) Echothiophate
d) Pyridostigmine

7) Following are the uses of Bethanechol, except:

a) Neurogenic ileus
b) Congenital megacolon
c) Postpartum or postoperative urinary retention
d) All of the above

8) Which of the following muscarinic antagonist is used to prevent or decrease vestibular disturbances, motion sickness?

a) Atropine
b) Scopolamine
c) Homatropine
d) Tropicamide

9) Which antimuscarinic agent is effective in the treatment of mushroom poisoning?

a) Pralidoxime
b) Pilocarpine
c) Atropine
d) Homatropine

10) In organophosphate poisoning, the drug is given to relieve neuromuscular manifestation is…………………........?

a) Pralidoxime
b) Atropine
c) Homatropine
d) Benzodiazepines

11) All of the following actions are mediated by muscarinic receptors except:

a) Negative chronotropic and inotropic effects
b) Detrusor muscle contraction and relaxation of trigone and sphincter muscles of the urinary bladder
c) Decreased peristalsis and contraction of the gastrointestinal tract
d) Increased peristalsis and relaxation of the gastrointestinal tract

12) Following statements about indirect-acting adrenergic agonists are true except:

a) Interaction with a specific adrenoceptor
b) Release of the endogenous catecholamines
c) Do not bind to specific receptor
d) Inhibition of the reuptake of catecholamines already released

13) Which of the following alpha-adrenergic blocking drugs show the first dose phenomenon?

a) Yohimbine
b) Phentolamine
c) Tolazoline
d) Prazosin

14) Metoprolol is different from propranolol in the following context;

a) Metoprolol is less likely to cause bronchoconstriction
b) Metoprolol has selectivity for beta-2 adrenoceptor
c) Metoprolol is used to treat hypertension
d) Metoprolol inhibits renin release from the kidney

15) Following agent act by competitive antagonism at the neuromuscular junction of nicotinic cholinoceptors:

a) Isoflurophate
b) Succinylcholine
c) Dantrolene
d) Atracurium

16) Drug of choice for the treatment of altitude sickness is ………………….......?

a) Timolol
b) Pilocarpine
c) Acetazolamide
d) Neostigmine

17) A patient with antimuscarinic toxicity shows the following symptoms:

a) Blurred vision
b) Xerostomia
c) Urinary retention
d) All of the above

18) Which of the following drug is the β blocker with an additional vasodilatory effect?

a) Propanolol
b) Carvedilol
c) Pindolol
d) Nadolol

19) All of the following are the adverse effects of selective β 2 agonists, except

a) Tremor
b) Tachycardia
c) Hyperglycemia
d) Hyperkalemia

20) Which of the following agent is used to treat malignant hyperthermia?

a) Dantrolene
b) Atracurium
c) Succinylcholine
d) Mecamylamine


Multiple Choice Answers:
1-c) Inhibition of hydrolysis of endogenous acetylcholine
2-b)Echothiophate
3-a)Edrophonium
4-c)Varenicline
5-d)M3
6-b)Physostigmine
7-d)All of the above
8-b) Scopolamine
9-c) Atropine
10-a) Pralidoxime
11-c)Decreased peristalsis and contraction of the gastrointestinal tract
12-a) Interaction with a specific adrenoceptor
13-d) Prazosin
14-a)Metoprolol is less likely to cause bronchoconstriction
15-d) Atracurium
16-c) Acetazolamide
17-d) All of the above
18-b) Carvedilol
19-d) Hyperkalemia
20-a) Dantrolene