Drug for treatment of Musculoskeletal disease: MCQ

Drug for treatment of Musculoskeletal disease
Multiple Choice Question on 

1) Following statements about non-steroidal anti-inflammatory drugs are true except:
a) Cause relief of pain – analgesic effect
b) Suppress the signs and symptoms of inflammation
c) Exerts anti-pyretic effects
d) All of the above
e) None of the above

2) The constitutive cyclooxygenase-1 enzyme responsible for
a) Gastrointestinal cytoprotection
b) Renal blood flow maintenance and electrolyte homeostasis
c) Platelets aggregation
d) Option a, b and c
e) Option a and b only

3) High dose of aspirin (more than 4 gm/day) is eliminated by ……………… kinetics
a) Zero-order
b) First order

4) Followings are the features of salicylism except:
a) Tinnitus
b) Blurred vision
c) Hyperventilation
d) All of the above

5) The following statements on aspirin are true except:
a) Aspirin displaces oral anticoagulants from its plasma protein binding sites and increases its activities leading to toxicity
b) Enhances the uricosuric effects of probenecid and sulphinpyrazone
c) Barbiturate increases the analgesic effect of aspirin
d) Aspirin displaces oral hypoglycemics from its plasma protein binding sites and increases its activities leading to toxicity

6) Followings are the acetic acid derivates of NSAIDs except:
a) Nimesulide
b) Sundilac
c) Indomethacin
d) Diclofenac

7) NSAID used for the treatment of patent ductus arteriosus in premature babies is
a) Naproxen
b) Diclofenac
c) Indomethacin
d) Piroxicam

8) Reye’s syndrome is an adverse effect of ………………
a) Paracetamol
b) Ibuprofen
c) Sundilac
d) Aspirin

9) An antidote for acute paracetamol toxicity is …………………….
a) N-acetylcysteine
b) Charcoal
c) Vitamin K
d) None of the above


10) ………………. is used as an analgesic, not an as anti-inflammatory agent
a) Nimesulide
b) Piroxicam
c) Ketorolac
d) Indomethacin

11) Which one of the following statements concerning COX-2 inhibitors is correct?
a) The COX-2 inhibitors show greater analgesic activity than traditional NSAIDs
b) The COX-2 inhibitors show anti-inflammatory activity similar to that of traditional NSAIDs
c) The COX-2 inhibitors are cardioprotective
d) The COX-2 inhibitors decrease platelet function

12) Which of the following anti-gout drug acts by inhibition of uric acid synthesis?
a) Probenecid
b) Sulfinpyrazone
c) Colchicine
d) Allopurinol

13) Following statements about colchicine for treatment of gout is true except:
a) Acts by the arrest of the metaphase stage of multiplying inflammatory cells at the site of inflammation
b) Helps in reducing pain and inflammation of gout
c) Colchicine may rarely cause serious muscle damage, rhabdomyolysis
d) Can be used as a pain medication to relieve other causes of pain

14) The following statement about Probenecid is true except
a) High dose probenecid decreases the proximal tubular reabsorption of uric acid
b) High dose probenecid increases the proximal tubular reabsorption of uric acid
c) Low dose probenecid decreases the proximal tubular reabsorption of uric acid
d) Low dose probenecid increases the distal tubular secretion of uric acid


15) Phase II block phenomenon during skeletal muscle relaxation is seen in;
a) Rocuronium
b) Succinylcholine
c) Dantrolene
d) Orphenadrine

16) Which of the following statement about Allopurinol is correct?
a) Allopurinol inhibits the effect of Azathioprine and 6-mercaptopurine
b) Allopurinol potentiates the effect of Azathioprine and 6-mercaptopurine
c) Allopurinol dissolves uric acid crystals and limits the formation of new ones
d) Allopurinol belongs to a uricosuric class of drugs

17) The primary toxicity leading to death from an acetaminophen overdose is ……………….
papillary necrosis and chronic interstitial nephritis
a) pancytopenia
b) hepatocellular necrosis
c) myocarditis

18) The immunosuppressive effect of methotrexate is a result of its inhibition of which of these?
a) Dihydrofolate reductase
b) Leukocyte migration
c) Microtubule function
d) Phospholipase A2

19) Indomethacin causes the following adverse effects except:
a) Gastric irritation
b) Mental confusion
c) Decreased risk of bleeding due to increased platelet aggregability
d) Reduces Na+ excretion leading to increased fluid retention and fluid overload

20) All of the followings are intermediate acting non-depolarizing competitive skeletal muscle relaxants except:
a) Mivacurium
b) Vecuronium
c) Rocuronium
d) Atracurium

Multiple Choice Answers

1-d) All of the above
2- d) Options a, b and c
3-a) Zero-order
4-d) All of the above
5-b) Enhances the uricosuric effects of probenecid and sulphinpyrazone
6-a) Nimesulide
7-c) Indomethacin
8-d) Aspirin
9-a) N-acetylcysteine
10-c) Ketorolac
11-b) The COX-2 inhibitors show anti-inflammatory activity similar to that of traditional NSAIDs
12-d) Allopurinol
13-d) Can be used as a pain medication to relieve other causes of pain
14-a) High dose probenecid decreases the proximal tubular reabsorption of uric acid
15-b) Succinylcholine
16-b) Allopurinol potentiates the effect of Azathioprine and 6-mercaptopurine
17-b) hepatocellular necrosis
18-a) Dihydrofolate reductase
19-c) Decreased risk of bleeding due to increased platelet aggregability
20-a) Mivacurium