MCQ on Hemoglobin & Hemoglobinopathies

Multiple Choice Question of Hemoglobin and Hemoglobinopathies


1) Hemoglobin is a heme-containing globular protein present in erythrocytes. Which of the following is the function of hemoglobin
a) Storage of oxygen
b) Transport of oxygen
c) Both of the above
d) None of the above

2) Adult hemoglobin (HbA) is a tetrameter consisting of 
a) α2β2
b) α2δ2
c) α2γ2
d) β4

3) Which of the following is the oxygen binding site of the hemoglobin  
a) N-terminal of the beta subunit 
b) Carboxyterminal of both alpha and beta subunits
c) Ferric ion (Fe+3) of the heme molecule
d) Ferrous ion (Fe+2) of the heme molecule

4) Identify the correct statements regarding hemoglobin (HbA) from the following 
a) HbA shows hyperbolic oxygen dissociation curve 
b) HbA shows sigmoidal oxygen dissociation curve 
c) T-state favors the oxygen binding to hemoglobin
d) R-state favors the oxygen binding to hemoglobin

5) The following allosteric regulators favor the unloading of oxygen in the peripheral tissues 
a) Low pH
b) Low 2-3 Bisphosphoglycerate
c) Low partial pressure of carbon dioxide
d) All of the above

6) Carbononooxide poisoning decreases oxygen delivery and causes tissue hypoxia and may lead to death in untreated individuals. The carbon monoxide 
a) Bind to the N-terminal chain and decreases the affinity of oxygen to a heme 
b) Competitively binds to oxygen binding site of hemoglobin at higher affinity 
c) Competitively Interfere with the binding of 2,3 BPG to hemoglobin
d) All of the above
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Answers Key MCQ Hemoglobin & Hemoglobinopathies 

1)- b) Transport of oxygen
2)- a) α2β2
3)- d) Ferrous ion (Fe+2) of the heme molecule
4)- a) & d)
5)-a) Low pH
6- b) Competitively binds to oxygen binding site of hemoglobin at higher affinity 

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Suggesting Readings 
Hemoglobin Structure and Function
Genetic Basis of Hemoglobinopathies 


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