Pharmacology: MCQ on Antimicrobial Agents-II

Multiple Choice Question on Antimicrobial Agents

1) Which of the following antibiotic acts by inhibition of nucleic acid synthesis?
a) Penicillin
b) Quinolones
c) Sulphonamides
d) Cephalosporin

2) Followings are the second-generation quinolones except:
a) Gatifloxacin
b) Enoxacin
c) Ofloxacin
d) Ciprofloxacin

3) Which of the followings are the drug interactions of quinolones is correct?
a) Antacids, calcium supplements decrease the absorption of quinolones
b) Quinolones enhance the metabolism of theophylline
c) Antacids, calcium supplements increase absorption of quinolones
d) Increased metabolism of warfarin and caffeine

4) The mechanism of action of Trimethoprim is:
a) Inhibition of enzyme dihydropteroate synthetase
b) Activation of enzyme dihydrofolate reductase
c) Inhibition of enzyme dihydrofolate reductase
d) Activation of enzyme dihydrofolate reductase

5) All of the following combinations are true except:
a) Ciprofloxacin: inhibition of DNA gyrase
b) Polymyxin B: inhibition of 50s protein synthesis
c) Erythromycin: inhibition of 50s protein synthesis
d) Sulphonamide: inhibition of folic acid

6) Cotrimoxazole is a combination of drugs
a) Sulphonamide + Chloramphenicol
b) Sulphonamide + Lincomycin
c) Sulphonamide + Trimethoprim
d) Sulphonamide + Tetracycline

7) Following adverse effects are shown by the corresponding drugs are true except
a) Chloramphenicol: gray baby syndrome
b) Cefoperazone: disulfiram-like reactions
c) Tetracycline: Fanconi syndrome
d) Sulphonamide: red man syndrome

8) The following statement about quinolones is true except:
a) Inhibition of DNA gyrase
b) Gemifloxacin and Clinafloxacin are 4th generation quinolone
c) Norfloxacin is 1st generation quinolone and used in the treatment of UTI
d) Second generation quinolone has increased activity against gram-positive bacteria including S. pneumoniae

9) Ciprofloxacin should not be used with theophylline because 

a) It decreases the efficacy of theophylline
b) It increases the toxicity of theophylline
c) Decreases absorption of theophylline
d) Decreases the efficacy of ciprofloxacin

10) Prolonged therapy of …………………………… leads to the development of pseudomembranous colitis
a) Amikacin
b) Clindamycin
c) Streptomycin
d) Vancomycin

11) By binding to the fungal ergosterol and alters its cellular permeability is the mechanism of action of ……………………….
a) Ketoconazole
b) Griseofulvin
c) Clotrimazole
d) Amphotericin B

12) Most commonly used antifungal topically for suppression of local candida infection is …………………
a) Miconazole
b) Fluconazole
c) Nystatin
d) Flucytosine

13) The type of drug interactions between flucytosine and amphotericin B is ………………………
a) Synergism
b) Antagonism
c) Potentiation
d) Additive

14) Which antifungal acts by non-competitive inhibition of squalene epoxidase thereby inhibition of ergosterol synthesis?
a) Flucytosine
b) Griseofulvin
c) Terbinafine
d) Ketoconazole

15) For the treatment of tinea cruris and tinea corporis, which topical allylamine(s) can be used?
a) Terbinafine
b) Naftifine
c) Both
d) None of the above

16) Gynecomastia and menstrual irregularities are the adverse effects of ………………
a) Terbinafine
b) Flucytosine
c) Griseofulvin
d) Ketoconazole

17) Followings are the correct combination of drug and its mechanism of action except:
a) Polyenes: binds to and disrupt the fungal cell membrane
b) Griseofulvin: blocks intracellular microtubules
c) Allylamines: inhibition of squalene epoxidase and blocks ergosterol formation in the cell membrane
d) Flucytosine: inhibition of cytochrome P450 dependent 14 α-demethylase and blocks ergosterol formation in the cell membrane

18) Flucytosine acts by
a) Inhibition of thymidylate synthetase leading to inhibition of DNA synthesis
b) Disruption of the mitotic spindle during metaphase by interacting with fungal microtubules
c) Inhibition of squalene epoxidase and blocks ergosterol formation in the cell membrane
d) None of the above

19) The most potent azoles antifungal is ………………….
a) Itraconazole
b) Fluconazole
c) Ketoconazole
d) Miconazole

20) Followings are the drug interactions of Ketoconazole except:
a) Inhibition of the metabolism of cyclosporine thereby increasing its toxicity
b) Enhanced metabolism of Astemizole and Terfenadine thereby decreasing arrhythmias
c) Cimetidine interferes with Ketoconazole absorption by increasing gastric pH
d) Rifamycins increase Ketoconazole hepatic metabolism

Multiple Choice Answers
1-b) Quinolones
2-a) Gatifloxacin
3-a) Antacids, calcium supplements decrease the absorption of quinolones
4-c) Inhibition of enzyme dihydrofolate reductase
5-b) Polymyxin B: inhibition of 50s protein synthesis
6-c) Sulphonamide + Trimethoprim
7-d) Sulphonamide: red man syndrome
8-d) Second generation quinolone has increased activity against gram-positive bacteria including S. pneumoniae
9-b) It increases the toxicity of theophylline
10-b) Clindamycin
11-d) Amphotericin B
12-c) Nystatin
13-a) Synergism
14-c)Terbinafine
15-c) Both
16-d) Ketoconazole
17-d)  Flucytosine: inhibition of cytochrome P450 dependent 14 α-demethylase and blocks ergosterol formation in the cell membrane
18-a) Inhibition of thymidylate synthetase leading to inhibition of DNA synthesis
19-a) Itraconazole
20-b) Enhanced metabolism of Astemizole and Terfenadine thereby decreasing arrhythmias