Immunology: Antigen Processing and Presentation MCQ

Multiple Choice Question on Antigen Processing and Presentation

1) The cells that display peptides associated with class II MHC molecules to CD4+ Th cells are called antigen presentation cells. Which of the following is not professional antigen-presenting cells
a) Dendritic cells
b) Macrophages
c) B cells
d) Fibroblast

2) The professional antigen-presenting cells different antigen uptake, constitutive MHC expression, and co-stimulatory activity. Which of the following is true
a) Dendritic cells constitutively express a high level of class II MHC molecules and co-stimulatory activity, they can activate naïve T cells.
b) Macrophage must be activated by phagocytosis of particular antigens before they express class II MHC molecules or co-stimulatory B-47 membrane molecules
c) B cells constitutively express class II MHC molecules but must be activated before they express the co-stimulatory signal
d) All of the Above


3) The antigenic peptide derived by class I are derived from the endogenous processing pathway. The researcher performed exposure of different antigens and obtained the following results. Emetine is a protein synthesis inhibitor and Chloroquine inhibits the endocytosis pathway.

Exposure Condition
MHC I restricted T-cell activation
Infectious Virus
+
Inactivated Non-infectious virus
-
Infectious virus + Emetine
-
Infectious virus + Cholorquine
+
Which of the following options is the correct answer?

a) MHC class I antigen presentation requires active infectious virus
b) The viral protein synthesis is required for MHC-Class I- peptide presentation
c) The endocytic pathway is not required for MHC-class I restricted activation
d) All of the above

4) The peptides for presentation on MHC-I are generated by protease complex called the proteasome.
a) The peptides are targeted for proteolysis with the attachment of ubiquitin
b) Ubiquitin-protein conjugate are recognized and degraded by a complex called proteasome
c) The proteasome-mediated proteolysis is ATP dependent
d) All of the above

5) The antigenic peptide derived by class II is derived from the exogenous processing pathway. The researcher performed exposure of different antigens and obtained the following results. Emetine is a protein synthesis inhibitor and Chloroquine inhibits the endocytosis pathway.

Exposure Condition 
MHC II-restricted T-cell activation
Infectious Virus
+
Inactivated Non-infectious virus
+
Infectious virus + Emetine
+
Infectious virus + Cholorquine
-

Which of the following options is the correct answer?
a) MHC class II presentation does not require active virus
b) The endogenous viral protein synthesis is not required for MHC-II peptide presentation
c) Inhibition of endocytic pathway hinders MHC class II-restricted T cell activation
d) None of the above

6) Transporter associated with antigen processing (TAP) is involved in the transport of the antigenic peptide from the cytosol to endoplasmic reticulum. Which of the following the correct answer?
a) TAP 1 & TAP 2 are class of ABC binding cassette proteins required for transport of processed peptide and they are highly polymorphic
b) TAP has the highest affinity for a peptide containing 8-10 amino acids and favors hydrophobic amino acids
c) Define mutation of TAP proteins lead to immunodeficiency and autoimmunity
d) All of the above

7) The chaperone is associated with free class Iα chain facilitate its folding and release after binding to β2 macroglobulin is
a) Calnexin
b) Calreticulin
c) Tapasin
d) Ubiquitin

8) Which of the following chaperones are bound to MHC class Iα chain and β2 microglobulin and facilitate the formation of MHC- class Iα, β2 microglobulin, and antigenic peptide trimers?
a) Calnexin & Calreticulin
b) Calreticulin & Tapasin
c) Calnexin & Tapasin
d) Calnexin & Ubiquitin

9) Which of the following mechanism is involved in the internalization of antigen by B cells?
a) Pinocytosis
b) Phagocytosis
c) Receptor-mediated endocytosis
d) All the above

10) Chloroquine is an inhibitor of the endocytic processing which
a) inhibits peptide uptake into cells
b) allosterically inhibit lysosomal proteases
c) increases the pH of lysosome and inactivation of lysosomal proteases
d) None of the above

11) Before loading of an antigenic peptide, MHC molecules exist in
a) monomers of α and β chain
b) dimers with an empty peptide-binding site
c) Trimers with peptide binding site with class II-associated invariant peptide
d) None of the above

12) Which of the following non-classical MHC molecule is required for the catalysis of exchange of CLIP peptide with antigenic peptide
a) HLA-DI
b) HLA- DM
c) HLA-DQ
d) HLA-DO

13) Which of the following non-classical MHC molecule impede the exchange of CLIP peptide with antigenic peptide
HLA-DI
HLA-DM
HLA-DQ
HLA-DO
14) Which of the following is not the characteristic feature of HLA DM
a) The HLA-DM is widely conserved among mammalian species
b) HLA is not polymorphic
c) HLA DM is present in the endosome
d) HLA is present in the cell surface

15) In B cell, the receptor that mediates the endocytosis of antigen is
a) MHC-II molecule
b) Membrane-bound antibody
c) CD41 antigen
d) CD20 antigen

16) The fate of the B-cell receptor that mediates antigen endocytosis is
a) The antigen is endocytosed and receptor remains at the surface
b) Both antigen and receptor are endocytosed but the receptor is recycled to the cell surface
c) Both antigen and receptor, processed and degraded
d) None of the above

17) Which of the following is true for the antigenic peptide that is presented via MHC class I and MHC class II?
a) They are non-covalently but stably bound to MHC
b) They are covalently bound to the MHC
c) The antigen peptide dissociate from MHC once it reaches the cell surface
d) The antigen can be replaced by other peptides on the cell membrane

18) The properties of CD1, a non-classical pathway for antigen presentation is
a) Similar to MHC class I, CD1 interacts with β2 microglobulin
b) The genes are located in chromosome 1
c) The antigen-binding site for CD1 is deeper and voluminous
d) All of the above

19) CD1 is mainly involved in the presentation of …………………….. and activation of T cells
a) Peptides
b) Lipopolysaccharides
c) Both
d) None
20) What is the characteristic feature of TAP deficiency?
a) Increased NK cells
b) Increased CD8+ T cells
c) Increased MHC class I expression cell surface
d) None of the above

Multiple Choice Answers Review 
1-d) Fibroblast
2-b) Macrophage must be activated by phagocytosis of particular antigens before they express class II MHC molecules or co-stimulatory B-47 membrane molecules
3-c) The endocytic pathway is not required for MHC-class I restricted activation
4- d) All of the above
5- d) None of the above
6-d) All of the above
7-a) Calnexin
8-b) Calreticulin & Tapasin
9-c) Receptor-mediated endocytosis
10-c) increases the pH of lysosome and inactivation of lysosomal proteases
11-c) Trimers with peptide binding site with class II-associated invariant peptide
12-b) HLA- DM
13- c) HLA-DQ
14- d) HLA is present in the cell surface
15-b) Membrane-bound antibody
16-b) Both antigen and receptor are endocytosed but the receptor is recycled to the cell surface
17- a) They are non-covalently but stably bound to MHC
18-d) All of the above
19-b) Lipopolysaccharides
20-a) Increased NK cells


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