Drug for the treatment of Gastrointestinal disease
Multiple Choice Question
1) All of the following drugs act by reducing gastric acid secretion except:
a) Omeprazole
b) Famotidine
c) Pirenzepine
d) Sucralfate
2) The following statement about Omeprazole is true except:
a) It is highly plasma protein bound
b) Its bioavailability is not affected by food
c) It is metabolized by the liver
d) It provides long-lasting acid suppression
3) Which of the following drugs have an anti-androgenic effect?
a) Ranitidine
b) Cimetidine
c) Famotidine
d) Nizatidine
4) All of the following statements about antacid are true except:
a) Weak bases that neutralize gastric pH
b) Inhibits the formation of pepsin
c) Aluminum antacids cause diarrhea and magnesium antacids cause constipation
d) Aluminum antacids cause constipation and magnesium antacids cause diarrhea
5) The following antiemetic act by blocking D2 receptor in the CTZ:
a) Metoclopramide
b) Cisapride
c) Chlorpromazine
d) Domperidone
6) ………………. interferes with the most of CYP450 enzymes and thus leads to many drug interactions.
a) Famotidine
b) Omeprazole
c) Ondansetron
d) Cimetidine
7) Which one of the following is the less frequent side effect of Metronidazole?
a) Anorexia
b) Metallic taste
c) Glossitis
d) Abdominal cramps
8) The drug of choice for single dose treatment of onchocerciasis and strongyloidiasis is ……………
a) Ivermectin
b) Diethylcarbamazine citrate
c) Tetramisole
d) Niclosamide
9) Which of the following is a stool softener that has no effect on fat-soluble vitamins?
a) Castor oil
b) Phenolphthalein
c) Cascara Sagrada
d) Docusate sodium
10) All of the following are the rationale of ORS composition except:
a) It is isotonic
b) Glucose facilitates Na+ absorption
c) Enough K+ to replenish losses in loose stool
d) All of the above
11) The following laxative lowers blood ammonia level in hepatic encephalopathy:
a) Bisacodyl
b) Liquid paraffin
c) Magnesium sulfate
d) Lactulose
12) Which one of the following statements for Albendazole is not true?
a) Absorption may be enhanced by administration with a fatty meal
b) Inhibits microtubule polymerization
c) Does not undergo first-pass metabolism
d) Eliminated in the bile
13) All of the following are the mechanism of action of metoclopramide except
a) D2 antagonism
b) 5-HT4 agonism
c) 5-HT3 antagonism
d) 5-HT4 antagonism
14) Which of the following is the most effective drug for motion sickness?
a) Hyoscine
b) Chlorpromazine
c) Prochlorperazine
d) Haloperidol
15) All of the following describes the drug interaction with metoclopramide except
a) Increases absorption aspirin
b) Reduces absorption of digoxin
c) Additive sedative effects occur when taken with sedative
d) a and b
e) a, b and c
16) Tardive dyskinesia is a major adverse effect of ………………
a) Cisapride
d) Promethazine
c) Hyoscine
d) Metoclopramide
17) The following are examples of stimulant purgatives except
a) Lactulose
b) Bisacodyl
c) Senna
d) Castor oil
18) Followings are the indications of Octreotide except:
a) Secretory diarrhea due to carcinoid tumor
b) Diarrhea due to vagotomy
c) Diarrhea due to short bowel syndrome
d) Acute diarrhea
19) Which one of the following drug interactions with anti-diarrheal agents is not true?
a) Adsorbents increase the absorption of drugs like digoxin, quinidine, clindamycin, and hypoglycemic agents
b) Adsorbents cause increased bleeding time when given along with anticoagulants
c) Antacids can decrease the effects of anticholinergic anti-diarrheal drugs
d) Adsorbents decrease the absorption of drugs like digoxin, quinidine, clindamycin, and hypoglycemic agents
20) Choose the correct drug and its mode of action combinations
a) Liquid paraffin: stool softener
b) Bisacodyl: osmotic purgative
c) Lactulose: osmotic purgative
a) Ispaghula: bulk-forming
a) Liquid paraffin: stool softener
b) Bisacodyl: osmotic purgative
c) Lactulose: osmotic purgative
a) Ispaghula: bulk-forming
Multiple Choice Answers
1-d) Sucralfate
2-b) Its bioavailability is not affected by food
3-b) Cimetidine
4-d) Aluminum antacids cause constipation and magnesium antacids cause diarrhea
5-c) Chlorpromazine
6-d) Cimetidine
7-c) Glossitis
8-a) Ivermectin
9-d) Docusate sodium
10-d) All of the above
11-d) Lactulose
12-c) Does not undergo first-pass metabolism
13-d) 5-HT4 antagonism
14-a) Hyoscine
15-e) a, b and c
16-d) Metoclopramide
17-a) Lactulose
18-d) Acute diarrhea
19-a) Adsorbents increase the absorption of drugs like digoxin, quinidine, clindamycin, and hypoglycemic agents
20-b) Bisacodyl: osmotic purgative
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