MCQs on Drug For Treatment of Gastrointestinal Disease

Drug for the treatment of gastrointestinal disease 

Multiple Choice Question

1) All of the following drugs act by reducing gastric acid secretion, Except:
a) Omeprazole
b) Famotidine
c) Pirenzepine
d) Sucralfate

2) The following statement about Omeprazole is true, Except:
a) It is highly plasma protein-bound
b) Its bioavailability is not affected by food
c) It is metabolized by the liver
d) It provides long-lasting acid suppression

3) Which of the following drugs have an anti-androgenic effect?
a) Ranitidine
b) Cimetidine
c) Famotidine
d) Nizatidine

4) All of the following statements about antacid are true, Except:
a) Weak bases that neutralize gastric pH
b) Inhibits the formation of pepsin
c) Aluminum antacids cause diarrhea and magnesium antacids cause constipation
d) Aluminum antacids cause constipation and magnesium antacids cause diarrhea

5) The following antiemetic act by blocking D2 receptor in the CTZ:
a) Metoclopramide
b) Cisapride
c) Chlorpromazine
d) Domperidone

6) ………………......interferes with most of the CYP450 enzymes and thus leads to many drug interactions.
a) Famotidine
b) Omeprazole
c) Ondansetron
d) Cimetidine

7) Which one of the following is the less frequent side effect of Metronidazole?
a) Anorexia
b) Metallic taste
c) Glossitis
d) Abdominal cramps

8) The drug of choice for single-dose treatment of onchocerciasis and strongyloidiasis is ……………...............?
a) Ivermectin
b) Diethylcarbamazine citrate
c) Tetramisole
d) Niclosamide

9) Which of the following is a stool softener that has no effect on fat-soluble vitamins?
a) Castor oil
b) Docusate sodium
c) Cascara Sagrada
d) Phenolphthalein

10) All of the following are the rationale of ORS composition, Except:

a) It is isotonic
b) Glucose facilitates Na+ absorption
c) Enough K+ to replenish losses in loose stool
d) All of the above

11) Which of the following laxative lowers blood ammonia levels in hepatic encephalopathy?
a) Lactulose
b) Liquid paraffin
c) Magnesium sulfate
d) Bisacodyl

12) Which one of the following statements for Albendazole is not true?
a) Absorption may be enhanced by administration with a fatty meal
b) Inhibits microtubule polymerization
c) Does not undergo first-pass metabolism
d) Eliminated in the bile

13) All of the following are the mechanism of action of metoclopramide except
a) D2 antagonism
b) 5-HT4 agonism
c) 5-HT3 antagonism
d) 5-HT4 antagonism

14) Which of the following is the most effective drug for motion sickness?
a) Hyoscine
b) Chlorpromazine
c) Prochlorperazine
d) Haloperidol

15) All of the following describes the drug interaction with metoclopramide except
a) Increases absorption of aspirin
b) Reduces absorption of digoxin
c) Additive sedative effects occur when taken with sedative
d) a and b
e) a, b and c

16) Tardive dyskinesia is a major adverse effect of ……………….........
a) Cisapride
d) Promethazine
c) Hyoscine
d) Metoclopramide

17) All of the following are examples of stimulant purgatives, Except
a) Lactulose
b) Bisacodyl
c) Senna
d) Castor oil

18) Followings are the indications of Octreotide except:
a) Secretory diarrhea due to carcinoid tumor
b) Diarrhea due to vagotomy
c) Diarrhea due to short bowel syndrome
d) Acute diarrhea

19) Which one of the following drug interactions with anti-diarrheal agents is not true?
a) Adsorbents increase the absorption of drugs like digoxin, quinidine, clindamycin, and hypoglycemic agents
b) Adsorbents cause increased bleeding time when given along with anticoagulants
c) Antacids can decrease the effects of anticholinergic anti-diarrheal drugs
d) Adsorbents decrease the absorption of drugs like digoxin, quinidine, clindamycin, and hypoglycemic agents

20) Choose the correct drug and its mode of action combinations:
a) Liquid paraffin: stool softener
b) Bisacodyl: osmotic purgative
c) Lactulose: osmotic purgative
d) Ispaghula: bulk-forming 

Answers:

1-d) Sucralfate 

2-b) Its bioavailability is not affected by food 

3-b) Cimetidine 

4-d) Aluminum antacids cause constipation and magnesium antacids cause diarrhea 

5-c) Chlorpromazine 

6-d) Cimetidine

7-c) Glossitis 

8-a) Ivermectin 

9-b) Docusate sodium 

10-d) All of the above 

11-a) Lactulose 

12-c) Does not undergo first-pass metabolism 

13-d) 5-HT4 antagonism 

14-a) Hyoscine 

15-e) a, b and c 

16-d) Metoclopramide 

17-a) Lactulose 

18-d) Acute diarrhea 

19-a) Adsorbents increase the absorption of drugs like digoxin, quinidine, clindamycin, and hypoglycemic agents 

20-b) Bisacodyl: osmotic purgative