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MCQ on Drug for the treatment of Respiratory Disease

MCQ on Drug for the treatment of Respiratory Disease

Drug for the treatment of Respiratory Disease
Multiple Choice Question
(Bronchial asthma, Tuberculosis, Antihistaminic, and Cough therapy)

1) All of the followings are selective β2-agonist except:
a) Isoprenaline
b) Salbutamol
c) Terbutaline
d) Formeterol

2) All of the following combinations of drug and its mechanism of action is correct except:
a) Salbutamol: stimulation of β2 receptor causing bronchodilation
b) Sodium cromoglicate: mast cell stabilization
c) Zafirlukast: leukotriene modulators
d) Theophylline: non-selective β2 receptor stimulation causing bronchodilation

3) Which of the following statement about Salmeterol is not true?
a) It acts by relaxing muscles in the airways to improve breathing
b) It is a short-acting selective β2 agonist
c) Salmeterol inhalation is used to prevent asthma attacks
d) Salmeterol inhalation is used to treat COPD including emphysema and chronic bronchitis

4) Which of the following inhibits acetylcholine-mediated bronchospasm?
a) Theophylline
b) Ephedrine
c) Ipratropium
d) Salmeterol

5) All of the following statements about the use of glucocorticoids in asthma is true except:
a) Reduces bronchial inflammation and hyperactivity to stimuli
b) Have delayed onset of action
c) Given as prophylactic medications, used alone or combined with β-agonists
d) They are bronchodilators

6) Systemic corticosteroids are indicated in the following conditions EXCEPT:
a) Mild episodic asthma
b) Severe chronic asthma
c) Status asthmaticus
d) To prevent neonatal respiratory distress syndrome


7) Which one of the following is not a side effect due to systemic corticosteroids?
a) Adrenal suppression
b) Fluid retention, weight gain, hypertension
c) Hyperglycemia
d) Sleep disorders

8) All of the following statements about histamine is true except:
a) Increases blood pressure
b) Stimulates gastric acid secretion
c) Causes dilatation of capillaries
d) Causes constriction of bronchial smooth muscles

9) Isoniazid-induced liver damage:
a) Occurs primarily in patients under 30 years of age
b) Occurs with increased frequency in patients receiving concomitant ethambutol therapy
c) is probably due to the formation of a toxic hydrazine metabolite that binds to liver protein
d) is frequently associated with allergic manifestations such as eosinophilia, fever, and rash.

10) Development of peripheral neuritis is associated with …………………
a) Rifampin
b) Ethambutol
c) Isoniazid
d) Streptomycin

11) Which of the following is the drug of choice in the treatment of productive cough?
a) Dextromethorphan
b) Pholcodine
c) Bromhexine
d) Noscapine

12) Astemizole and terfenadine may cause fatal arrhythmia when used in combination with some macrolides or antifungal agents. They
a) Lengthen QT interval via direct action on cardiac H2 receptors
b) Increase metabolism of macrolide antibiotics
c) Cause accumulation of these agents following inhibition of CYP3A4, a cytochrome p450 enzyme
d) Exacerbate histamine-induced hypotension causing increased cardiac oxygen demand during reflex tachycardia

13) Which one of the following statements about cough is correct?
a) Cough must always be treated with an anti-tussive regardless of its cause
b) Codeine is effective in the treatment of productive cough
c) Pentoxyverine is especially well suited to treat cough in infants
d) Angiotensin II receptor blockers can cause cough

14) Choose the correct statement about rifampin:
a) It is the most active drug on slow-growing tubercle bacilli
b) Its antitubercular efficacy is lower than that of isoniazid
c) It is active against many atypical mycobacteria
d) It does not effectively cross the blood-CSF barrier


15) What is a serious adverse reaction caused by ethambutol?
a) Stomach upset
b) Eye damage
c) Gout
d) Hepatotoxicity

16) Choose the correct drug and its mechanism of action combination:
a) Rifampicin: inhibits bacterial DNA-dependent RNA polymerase
b) Pyrazinamide: interferes mycobacteria fatty acid synthesis and inactivates mycobacteria at alkaline pH
c) Ethambutol: Interferes with mycolic acid synthesis
d) Isoniazid: Inhibits arabinosyl transferases involved in cell wall biosynthesis
17) The following anti-tubercular drug is a potent CYP-P450 enzyme inducer:
a) Isoniazid
b) Ethambutol
c) Rifampicin
d) Pyrazinamide

18) Which of the following pharmacologic agents antagonizes adenosine?
a) Theophylline
b) Glucocorticoids
c) Cromolyn sodium
d) Terbutaline

19) All of the following statements about antihistaminic are correct EXCEPT:
a) Some histamine H1 receptor antagonists are used in the prophylaxis and treatment of motion sickness
b) Promethazine possesses anti-emetic, sedative and anti-muscarinic activity
c) Histamine H1 receptor antagonists inhibit the release of histamine
d) Histamine H1 receptor antagonists are effective in the treatment of hay fever

20) An anti-tubercular drug which is bacteriostatic to resting organism is………….
a) Pyrazinamide
b) Isoniazid
c) Ethambutol
d) Rifampicin

Multiple Choice Answers
1-a) Isoprenaline
2-d)Theophylline: non-selective β2 receptor stimulation causing bronchodilation
3-b) It is a short-acting selective β2 agonist
4-c) Ipratropium
5-d) They are bronchodilators
6-a) Mild episodic asthma
7-d) Sleep disorders
8-a) Increases blood pressure
9-c) is probably due to the formation of a toxic hydrazine metabolite that binds to liver protein
10-c) Isoniazid
11-c) Bromhexine
12-c) cause accumulation of these agents following inhibition of CYP3A4, a cytochrome p450 enzyme
13-d) Angiotensin II receptor blockers can cause cough
14-c) It is active against many atypical mycobacteria
15-b) Eye damage
16-a) Rifampicin: inhibits bacterial DNA-dependent RNA polymerase
17-c) Rifampicin
18-a) Theophylline
19-c) Histamine H1 receptor antagonists inhibit the release of histamine
20-b) Isoniazid


Author: Ronak Shrestha
MCQ on Drug for the treatment of Respiratory Disease MCQ on Drug for the treatment of Respiratory Disease Reviewed by Biotechnology on June 13, 2019 Rating: 5

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