MCQ on Systemic Mycoses (Medical Mycology)

Multiple Choice Question  on Systemic Mycoses 

1) All of the following are the characteristics of systemic mycoses/deep mycosis, EXCEPT?
a) Most of the dimorphic fungi cause the infection
b) Pathogenesis mostly occurs due to the inhalation of spores
c) Lungs are the site of infections for all of the fungi
d) Infection can develop in immunocompromised individuals 

2) Blastomyces dermatitidis is a dimorphic fungus that exists as yeast or mold depending upon its growth temperature, all of the following are the characteristics of yeast form of B. dermatitidis, EXCEPT?
a) The incubation temperature is 25-degree Celsius
b) It reproduces by the formation of blastoconidia
c) The cells are spherical in shape with a thick double layer wall
d) Amphotericin is the drug of choice

3) Coccidioidomycosis has the lesions the same as that of the lesion caused by which of the following infections?

a) Sporotrichosis 

b) Brucellosis

 c) Syphilis

d) Candidiasis

4) Which of the following statement is true for the direct examination of sputum or tissue sample taken from coccidioidomycosis?

a) Identification of budding yeast with its pseudo hyphae 

b) The detection of spherules with endospores in sputum or tissue

c) The saprophytic phase is observed as septate mycelium with pyriform conidia
d) Tuberculate microconidia are observed in culture

5) What is the other name for the coccidioidomycosis?
a) Yellow fever
b) San Joaquin Valley fever
c) Rocky mountain fever
d) Relapsing fever

6) A farmer in the Midwest of America developed a flu-like symptoms with fever, headache, muscle pain and cough since a week. Swabs specimens and the sputum sample was taken, radiography examination was also performed which showed diffused bilateral pneumonia. After a week of culture, white mold colonies were observed with large and small conidia. Name the possible pathogen the farmer is exposed to?
a) Coccidioidomycosis
b) Sporotrichosis
c) Histoplasmosis
d) Blastomycoses

7) What could be the source for the given above disease?
a) Hen
b) Horse
c) Cow
d) Pig

8) Which of the following is the usual route of infection for histoplasmosis?
a) Nose
b) Skin Wound
c) Both of the above
d) None of the above

9) All of the following statements are true about Histoplasmosis duboisii, EXCEPT?
a) Mostly affects the skin and bone
b) This type of infection is confined to African regions
c) The usual entry of pathogen is through the skin abrasions
d) None of the above

10) Which of the following is most susceptible to Blastomycoses?
a) Dogs
b) Pigs
c) Hens
d) Pigeons

11) Which of the following pathogen from sputum specimen shows mold growth with tuberculate macroconidia and oval microconidia during the laboratory examination?
a) Histoplasma capsulatum
b) Coccidioides immitis
c) Blastomyces dermatitidis
d) Paracoccidioides brasiliensis

12) Which of the following pathogen causes the fungal infection South American Blastomycosis?
a) Histoplasma duboisii
b) Blastomyces dermatitidis
c) Paracoccidioides brasiliensis 
d) Coccidioides immitis

13) What is the drug of choice for Paracoccidioidomycoses?
a) Amphotericin B
b) Voriconazole
c) Caspofungin
d) Itraconazole

14) Which of the following pathogen is found in soil having high nitrogen content?
a) Histoplasma capsulatum
b) Blastomyces dermatitidis
c) Aspergillus niger
d) Coccidioides immitis

15) Which type of fungal spores is produced by Coccidioides immitis?
a) Macroconidia
b) Arthroconidia
c) Chlamydospores
d) Sporangia

16) Which of the following is Not the specimen usually taken for the diagnosis of Cryptococcus spp?
a) Urine
b) Sputum
c) Skin tissues
d) Cerebrospinal fluid
e) Blood

17) All of the following fungi are the common laboratory contaminants and an important part of the medical mycology which causes systemic infection, Except?
a) Penicillium spp 
b) Cryptococcus spp
c) Aspergillus spp
d) Mucor spp
e) Rhizopus spp

18) Thousands of people in western part of the USA suddenly developed a flu or pneumonia like symptoms in 1992, the causative agent later diagnosed as fungal spores. After inhalation of the spores present in the soil and air people suffered from fever, cough and fatigue, later the disease was termed as valley fever. Name the possible pathogen?
a) Aspergillus niger
b) Paracoccidioides brasiliensis
c) Blastomyces dermatidis
d) Coccidioides immitis

19) The combination of yeast extract, phosphate medium and ammonium hydroxide is useful in identification of which of the following fungi that could be present in the sputum specimen of the suspected individual?
a) Histoplasma spp and Blastomyces spp
b) Mucor spp and Aspergillus spp
c) Cryptococcus spp and Sprothrix spp
d) Penicillium spp and Candida spp

20) Which of the following fungal infection can occur in dogs?
a) Coccidioidomycosis
b) Histoplasmosis
c) Blastomycosis
d) Sporotrichosis

1-c) Lungs are the site of infections for all the fungi 
2-a) The incubation temperature is 25-degree Celsius
3-c) Syphilis
4-b) The detection of spherules with endospores in sputum or tissue
5-b) San Joaquin Valley fever
6-c) Histoplasmosis
7-a) Hen
8-a) Nose
9-c) The usual entry of pathogen is through the skin abrasions
10-a) Dogs
11-a) Histoplasma capsulatum
12-c) Paracoccidioides brasiliensis 
13-d) Itraconazole
14-a) Histoplasma capsulatum 
15-b) Arthroconidia
16-c) Skin tissues
17- b) Cryptococcus spp
18- d) C. immitis
19- a) 
20- c) Blastomycosis

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