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Fatty acid synthesis: MCQ of the day


Q) In what compartment does the de novo fatty acid synthesis occurs?

a) Mitochondria
b) Perioxosome
c) Endoplasmic reticulum
d) Cytosol

Explanation
Fatty acid biosynthesis takes place in the cytosol
Intermediates covalently linked to an acyl carrier protein
The acetyl CoA is activated to malonyl CoA
Four steps repeating cycle are condensation, reduction, dehydration, and reduction. One cycle leads to extension by 2-carbons

Comparison of Fatty acid synthesis and oxidation

Characteristics
Synthesis
Degradation
Location
Cytosol
Mitochondrial Matrix
Activated Intermediates
Bound to ACP
Thioester of CoA
Enzymes
FAS is a multienzyme complex
4 distinct enzymes
Substrate
Acetly CoA
Fatty Acids
Direction
Starts at methyl end
Starts at the carboxyl end
Cofactors
NADPH
FADH/NADH
Major sites
Liver
Muscle and Liver
Hormonal Regulation
High Insulin/Glucagon ratio
Low Insulin/Glucagon ratio
Activator
Citrate
Free fatty acids
Inhibitor
Fatty acyl CoA
Malonyl CoA




Fatty acid synthesis: MCQ of the day Fatty acid synthesis: MCQ of the day Reviewed by Biotechnology on November 26, 2017 Rating: 5

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