Immunology: MCQ on Immune Tolerance & Autoimmunity

Multiple Choice Question on  Immune Tolerance & Autoimmunity

1) Which of the following option is the mechanism for induction of immune tolerance?
a) Central Anergy
b) Peripheral Anergy
c) Clonal Anergy
d) All of the above

2) The central tolerance occurs in thymus and bone marrow. Which of the following statement is true regarding central tolerance?
a) The positive selection occurs in cortex before maturing and entering the circulation.
b) The negative selection occurs in the medulla.
c) The negative selection removes cells that have high affinities for self-antigen
d) All of the above

3) After exiting thymus, mature T cells are subjected to the secondary selection where the majority of self-reactive T cells are deleted or rendered anergic. The process is known as
a) Central Anergy
b) Peripheral Anergy
c) Clonal Anergy
d) All of the above 

4) Certain autoimmune disorders are monogenic-caused by a mutation in a single gene. The following are the monogenic autoimmune disease except:
a) Autoimmune lymphoproliferative syndrome
b) Autoimmune polyadenopathy
c) Immunodysregulation polyendocrinopathy (X-linked)
d) Systemic Lupus Erythematosus

5) The autoimmune thyroid disorder with a presence of anti-TSH receptor antibody is suggestive of:
a) Hashimoto thyroiditis
b) Grave's disease
c) Goodpasture syndrome
d) None of the above

6) Which of the following is the multifactorial autoimmune disorder?
a) Multiple Sclerosis
b) Rheumatic fever
c) Autoimmune hepatitis
d) Lymphoproliferative syndrome

7) The antibody generated against the intrinsic factor in the gastric tissue leads to
a) Goodpasture syndrome
b) Pernicious anemia
c) Celiac disease
d) None of the above

8) The autoimmune disorder with an elevated anti-thyroglobulin antibody is
a) Hashimoto thyroiditis
b) Grave's disease
c) Goodpasture syndrome
d) None of the above

9) The presence of anti-glutamic acid decarboxylase antibodies increased the susceptibility to
a) Type 1 Diabetes mellitus
b) Celiac disease
c) Grave's disease
d) Pernicious anemia 

10) The following antibodies not associated with Systemic Lupus Erythematosus EXCEPT?
a) Anti-ANA antibody
b) Anti-cardiolipin antibody
c) Anti-dsDNA
d) None of the above

11) In Rheumatic fever, the cross-reactivity between the bacterial M protein and human lysoganglioside that lead to the development of cardiac T cells. M protein is a cell wall component of
a) Staphylococcus aureus
b) Streptococcus pyogenes
c) Hemophilus influenza
d) Neisseria gonorrhea 

12) The generation of reactive cells against HHV-6 encoded U24 cross-reactive with myelin basic protein resulting in autoimmune disease
a) Myasthenia gravis
b) Multiple sclerosis
c) Grave's disease
d) Systemic Lupus Erythematosus

13) Myasthenia Gravis is caused by the production of autoantibodies against
a) Myelin basic proteins
b) TSH receptor
c) Acetylcholine receptor
d) None of the above

14) Which of the following MHC allelic form is protective against ulcerative colitis?
a) HLA class II DR2
b) HLA class II DR4
c) HLA class II DR15
d) HLA class II DR9

15) The B27 HLA allele is associate the following condition
a) Ankylosing spondylitis
b) Psoriasis
c) Inflammatory bowel disease
d) All of the above

Multiple Choice Answers
1-d) All of the above
2-d) All of the above
3-b) Peripheral Anergy
4-d) Systemic Lupus Erythematosus
5-b) Grave's disease
6-d) Lymphoproliferative syndrome
7-b) Pernicious anemia
8-a) Hashimoto thyroiditis
9-a) Type 1 Diabetes mellitus
10-d) None of the above
11-b) Streptococcus pyogenes
12-b) Multiple sclerosis
13-c) Acetylcholine receptor
14-b) HLA class II DR4
15-d) All of the above


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