MCQs on Smallpox virus (Poxvirus)
1. Who is credited with the discovery of vaccination using cowpox to protect against smallpox?
a) Edward Jenner
b) Jonas Salk
c) Louis Pasteur
d) Robert Koch
Click World Health Organization (WHO) website for more questions and answers about smallpox: https://www.who.int/news-room/questions-and-answers/item/smallpox
Figure1: cowpox and smallpox pustules
a) Edward Jenner
b) Jonas Salk
c) Louis Pasteur
d) Robert Koch
2. Smallpox exists as two distinct subtypes, Variola major and Variola minor. Which subtype caused more severe disease with a higher case fatality rate?
a) Variola major
b) Variola minor
3. The genetic material of poxviruses is composed of:
a) Single-stranded RNA
b) Double-stranded RNA
c) Single-stranded DNA
d) Double-stranded DNA
4. Which of the following is NOT a disease caused by a poxvirus?
a) Monkeypox
b) Chickenpox
c) Cowpox
d) Smallpox
5. Which of the following statements about poxvirus replication is true?
a) Poxviruses replicate in the host cell's nucleus.
b) Poxviruses use reverse transcriptase to replicate their DNA.
c) Poxviruses replicate in the host cell's cytoplasm.
d) Poxviruses do not replicate in host cells; they are extracellular pathogens.
6. How do individual skin lesions in smallpox typically evolve throughout the illness?
a) Crusts to pustules to vesicles to papules to macules
b) Macules to papules to vesicles to pustules to crusts
c) Pustules to vesicles to papules to macules
d) Vesicles to papules to macules
7. Which of the following symptoms is not characteristic of smallpox?
a) Cough and respiratory distress
b) High fever
c) Lymphadenopathy
d) Papules and vesicles on the skin
8. What is the initial step in managing a suspected case of smallpox?
a) Administer antiviral medications
b) Administer antibiotics
c) Isolate the patient in a negative pressure room
d) Start vaccination immediately
9. Which diagnostic test is most likely to confirm the diagnosis of smallpox?
a) Chest X-ray
b) Complete Blood Count
c) PCR for smallpox virus in vesicle fluid
d) Skin biopsy
10. Smallpox is caused by which virus family?
a) Herpesviridae
b) Orthopoxvirus
c) Paramyxoviridae
d) Flaviviridae
11. When was the development of the smallpox vaccine in ?
a) 1796
b) 1850
c) 1925
d) 1967
12. What did Edward Jenner observe that led to the development of the smallpox vaccine?
a) Milkmaids who had cowpox were immune to smallpox.
b) Smallpox could be treated with antibiotics.
c) Smallpox was transmitted through contaminated water.
d) Smallpox was caused by a bacterium.
13. In smallpox, where does the emergence of skin lesions typically begin?
a) Forearms or face
b) Legs
c) Palms and soles
d) Torso
14. Which practice involved the deliberate inoculation of infectious smallpox from an infected person to a healthy individual in order to induce a milder disease course?
a) Inoculation
b) Immunization
c) Vaccination
d) Variolation
Answers:
1. c) Edward Jenner
2. a) Variola major
3. d) Double-stranded DNA
4. b) Chickenpox
5. c) Poxviruses replicate in the host cell's cytoplasm.
6. b) Macules to papules to vesicles to pustules to crusts
7. a) Cough and respiratory distress
8. c) Isolate the patient in a negative pressure room
9. c) PCR for smallpox virus in vesicle fluid
10. b) Orthopoxvirus
11. a) 1796
12. a) Milkmaids who had cowpox were immune to smallpox.
13. a) Forearms or face
14. d) Variolation
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