Gene editing is a genome engineering technology that allows us to make intended changes in the DNA. It includes ablating the target genes, inserting / deleting a segment of DNA to the target site, etc. CRISPR is a bacterial-derived gene-editing technology consisting of cas9 protein and guide RNA. The CRISPR technology is being explored for the curative intervention of genetic diseases including muscular dystrophy. The recent study by Gersbach lab published, in Nature Medicine, evaluated the long-term efficacy of AAV mediated CRISPR delivery in the treatment of Duchene muscular dystrophy. In this study, the authors reported corroborating data on the risk associated with AAV-CRISPR, a novel approach to evaluate these risks, and interesting results that pave the path for future research. The long-term and persistent expression of Cas9 / gRNA are observed in the mouse model of DMD (mdx null mice). The correction of dmd gene resulted in expression of the full-length dystrophin pro...